Journal article
Obesity and hypertension interact to increase risk of renal cell carcinoma in Iowa, USA
Obesity research & clinical practice, Vol.1(2), pp.I-153
05/2007
DOI: 10.1016/j.orcp.2007.02.004
PMID: 24351456
Abstract
Renal cell carcinoma (RCC) rates in the US have risen, along with those of obesity and hypertension. We investigated the interactive relationship with obesity and hypertension (HT) through a population-based case-control study of RCC in Iowa consisting of 406 cases and 2434 controls. Data on height and weight at various ages and history of HT were collected and interaction tested by log-likelihood ratio tests. After adjustment, both obesity and HT were independently and interactively associated with increased RCC risk. Hypertensive subjects, obese (BMI ≥ 30) at age 40 were 4.2 (CI: 2.38-6.53) times more likely to develop RCC as normotensive individuals of normal weight (BMI < 25). A similar interactive pattern was observed for obesity at age 60 (p = 0.02). Interaction with obesity was more evident in women (pinteraction = 0.04 age 40, pinteraction = 0.01 age 60). Our findings suggest that maintaining body weight and/or controlling HT are strategies for preventing RCC.:
Details
- Title: Subtitle
- Obesity and hypertension interact to increase risk of renal cell carcinoma in Iowa, USA
- Creators
- Kaye E Brock - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD, USA. Electronic address:k.brock@fhs.usyd.edu.auGloria Gridley - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD, USACharles F Lynch - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD, USAAbby G Ershow - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD, USAKenneth P Cantor - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD, USA
- Resource Type
- Journal article
- Publication Details
- Obesity research & clinical practice, Vol.1(2), pp.I-153
- DOI
- 10.1016/j.orcp.2007.02.004
- PMID
- 24351456
- ISSN
- 1871-403X
- eISSN
- 1878-0318
- Language
- English
- Date published
- 05/2007
- Academic Unit
- Epidemiology
- Record Identifier
- 9984214816302771
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