Obesity and late-age survival without major disease or disability in older women

Eileen Rillamas-Sun; Andrea Z LaCroix; Molly E Waring; Candyce H Kroenke; Michael J LaMonte; Mara Z Vitolins; Rebecca Seguin; Christina L Bell; Margery Gass; Todd M Manini; Kamal H Masaki; Robert B Wallace

doi:10.1001/jamainternmed.2013.12051

Back

Obesity and late-age survival without major disease or disability in older women

Journal article

Open access

Peer reviewed

Obesity and late-age survival without major disease or disability in older women

Eileen Rillamas-Sun, Andrea Z LaCroix, Molly E Waring, Candyce H Kroenke, Michael J LaMonte, Mara Z Vitolins, Rebecca Seguin, Christina L Bell, Margery Gass, Todd M Manini, …

JAMA internal medicine, Vol.174(1), pp.98-106

01/2014

DOI: 10.1001/jamainternmed.2013.12051

PMCID: PMC3963496

PMID: 24217806

Files and links (1)

url

https://doi.org/10.1001/jamainternmed.2013.12051View

Published (Version of record) Open Access

Abstract

The effect of obesity on late-age survival in women without disease or disability is unknown. To investigate whether higher baseline body mass index and waist circumference affect women's survival to 85 years of age without major chronic disease (coronary disease, stroke, cancer, diabetes mellitus, or hip fracture) and mobility disability. Examination of 36,611 women from the Women's Health Initiative observational study and clinical trial programs who could have reached 85 years or older if they survived to the last outcomes evaluation on September 17, 2012. Recruitment was from 40 US clinical centers from October 1993 through December 1998. Multinomial logistic regression models were used to estimate odds ratios and 95% CIs for the association of baseline body mass index and waist circumference with the outcomes, adjusting for demographic, behavioral, and health characteristics. Mutually exclusive classifications: (1) survived without major chronic disease and without mobility disability (healthy); (2) survived with 1 or more major chronic disease at baseline but without new disease or disability (prevalent diseased); (3) survived and developed 1 or more major chronic disease but not disability during study follow-up (incident diseased); (4) survived and developed mobility disability with or without disease (disabled); and (5) did not survive (died). Mean (SD) baseline age was 72.4 (3.0) years (range, 66-81 years). The distribution of women classified as healthy, prevalent diseased, incident diseased, disabled, and died was 19.0%, 14.7%, 23.2%, 18.3%, and 24.8%, respectively. Compared with healthy-weight women, underweight and obese women were more likely to die before 85 years of age. Overweight and obese women had higher risks of incident disease and mobility disability. Disability risks were striking. Relative to healthy-weight women, adjusted odds ratios (95% CIs) of mobility disability were 1.6 (1.5-1.8) for overweight women and 3.2 (2.9-3.6), 6.6 (5.4-8.1), and 6.7 (4.8-9.2) for class I, II, and III obesity, respectively. Waist circumference greater than 88 cm was also associated with higher risk of earlier death, incident disease, and mobility disability. Overall and abdominal obesity were important and potentially modifiable factors associated with dying or developing mobility disability and major chronic disease before 85 years of age in older women.

Aged

Aged, 80 and over

Body Mass Index

Chronic Disease - epidemiology

Comorbidity

Disease-Free Survival

Female

Humans

Logistic Models

Mobility Limitation

Obesity - mortality

Obesity, Abdominal - mortality

Odds Ratio

Risk Factors

Thinness - mortality

Waist Circumference

Details

Title: Subtitle: Obesity and late-age survival without major disease or disability in older women
Creators: Eileen Rillamas-Sun - Kaiser Permanente Washington Health Research Institute
Andrea Z LaCroix - Fred Hutch Cancer Center
Molly E Waring - University of Massachusetts Chan Medical School
Candyce H Kroenke - Kaiser Permanente
Michael J LaMonte - University at Buffalo, State University of New York
Mara Z Vitolins - Wake Forest University
Rebecca Seguin - Cornell University
Christina L Bell - University of Hawaiʻi at Mānoa
Margery Gass - North American Menopause Society
Todd M Manini - University of Florida
Kamal H Masaki - University of Hawaiʻi at Mānoa
Robert B Wallace - University of Iowa
Resource Type: Journal article
Publication Details: JAMA internal medicine, Vol.174(1), pp.98-106
DOI: 10.1001/jamainternmed.2013.12051
PMID: 24217806
PMCID: PMC3963496
NLM abbreviation: JAMA Intern Med
ISSN: 2168-6106
eISSN: 2168-6114
Grant note: HHSN271201100004C / NIA NIH HHS HHSN268201100004I / NHLBI NIH HHS UL1 RR031982 / NCRR NIH HHS UL1RR031982 / NCRR NIH HHS K01HL108807-01 / NHLBI NIH HHS HHSN268201100003C / PHS HHS HHSN268201100004C / WHI NIH HHS P30 AG028740 / NIA NIH HHS HHSN268201100002C / WHI NIH HHS HHSN268201100004C / PHS HHS HHSN268201100003C / WHI NIH HHS T32 AG027677 / NIA NIH HHS UL1 TR000161 / NCATS NIH HHS P30 ES005605 / NIEHS NIH HHS HHSN268201100002I / NHLBI NIH HHS HHSN268201100046C / PHS HHS HHSN268201100001C / WHI NIH HHS K01 HL108807 / NHLBI NIH HHS U01HL105268 / NHLBI NIH HHS HHSN271201100004C / PHS HHS HHSN268201100046C / NHLBI NIH HHS KL2 TR000160 / NCATS NIH HHS HHSN268201100001I / NHLBI NIH HHS HHSN268201100002C / PHS HHS U01 HL105268 / NHLBI NIH HHS HHSN268201100001C / PHS HHS
Language: English
Date published: 01/2014
Academic Unit: Epidemiology; Injury Prevention Research Center; Internal Medicine
Record Identifier: 9984363613402771

Metrics

20 Record Views

59 Times Cited - Web of Science

See more details