Journal article
Obesity during childhood is associated with higher cancer mortality rate during adulthood: the i3C Consortium
International journal of obesity (2005), Vol.46(2), pp.393-399
02/2022
DOI: 10.1038/s41366-021-01000-3
PMCID: PMC8794778
PMID: 34728776
Abstract
In high-income countries, cancer is the leading cause of death among middle-aged adults. Prospective data on the effects of childhood risk exposures on subsequent cancer mortality are scarce.
We examined whether childhood body mass index (BMI), blood pressure, glucose and lipid levels were associated with adult cancer mortality, using data from 21,012 children enrolled aged 3-19 years in seven prospective cohort studies from the U.S., Australia, and Finland that have followed participants from childhood into adulthood. Cancer mortality (cancer as a primary or secondary cause of death) was captured using registries.
354 cancer deaths occurred over the follow-up. In age-, sex, and cohort-adjusted analyses, childhood BMI (Hazard ratio [HR], 1.13; 95% confidence interval [CI] 1.03-1.24 per 1-SD increase) and childhood glucose (HR 1.22; 95%CI 1.01-1.47 per 1-SD increase), were associated with subsequent cancer mortality. In a multivariable analysis adjusted for age, sex, cohort, and childhood measures of fasting glucose, total cholesterol, triglycerides, and systolic blood pressure, childhood BMI remained as an independent predictor of subsequent cancer mortality (HR, 1.24; 95%CI, 1.03-1.49). The association of childhood BMI and subsequent cancer mortality persisted after adjustment for adulthood BMI (HR for childhood BMI, 1.35; 95%CI 1.12-1.63).
Higher childhood BMI was independently associated with increased overall cancer mortality.
Details
- Title: Subtitle
- Obesity during childhood is associated with higher cancer mortality rate during adulthood: the i3C Consortium
- Creators
- Joel Nuotio - University of TurkuTomi T Laitinen - University of TurkuAlan R Sinaiko - University of MinnesotaJessica G Woo - Cincinnati Children's Hospital Medical CenterElaine M Urbina - Cincinnati Children's Hospital Medical CenterDavid R Jacobs Jr - University of MinnesotaJulia Steinberger - University of MinnesotaRonald J Prineas - Wake Forest UniversityMatthew A Sabin - Royal Children's HospitalDavid P Burgner - The University of MelbourneHeikki Minn - Turku University HospitalTrudy L Burns - University of IowaLydia A Bazzano - Tulane UniversityAlison J Venn - University of TasmaniaJorma S A Viikari - Turku University HospitalNina Hutri-Kähönen - Tampere University HospitalStephen R Daniels - University of IowaOlli T Raitakari - Turku University HospitalCostan G Magnussen - Turku University HospitalMarkus Juonala - Turku University HospitalTerence Dwyer - Martin University
- Resource Type
- Journal article
- Publication Details
- International journal of obesity (2005), Vol.46(2), pp.393-399
- DOI
- 10.1038/s41366-021-01000-3
- PMID
- 34728776
- PMCID
- PMC8794778
- NLM abbreviation
- Int J Obes (Lond)
- ISSN
- 0307-0565
- eISSN
- 1476-5497
- Grant note
- R01 HL121230 / NHLBI NIH HHS
- Language
- English
- Date published
- 02/2022
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984363600202771
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