Obesity is associated with muscle atrophy in rotator cuff tear

Simone Herzberg; Zhiguo Zhao; Thomas Freeman; Ravi Prakash; Keith Baumgarten; Julie Bishop; James Carey; Grant Jones; Eric McCarty; Edwin Spencer; Armando Vidal; Nitin Jain; Ayush Giri; John Kuhn; Michael Khazzam; Elizabeth Matzkin; Robert Brophy; Warren Dunn; C Benjamin; Robert Marx; Sourav Poddar; Matthew Smith; Brian Wolf; Rick Wright

doi:10.1136/bmjsem-2024-001993

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Obesity is associated with muscle atrophy in rotator cuff tear

Journal article

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Peer reviewed

Obesity is associated with muscle atrophy in rotator cuff tear

Simone Herzberg, Zhiguo Zhao, Thomas Freeman, Ravi Prakash, Keith Baumgarten, Julie Bishop, James Carey, Grant Jones, Eric McCarty, Edwin Spencer, …

BMJ Open Sport & Exercise Medicine, Vol.10(2), e001993

06/01/2024

DOI: 10.1136/bmjsem-2024-001993

PMCID: PMC11227827

PMID: 38974096

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Abstract

Objective The primary goal of this study is to evaluate the relationship between Body Mass Index (BMI) and muscle atrophy in individuals with rotator cuff tears.Methods This study consists of patients with rotator cuff tears identified by MRI from two independent cohorts, the Rotator Cuff Outcomes Workgroup (ROW) and the Multicenter Orthopaedic Outcomes Network (MOON). Presence of atrophy (yes/no) and severity of atrophy (as an ordinal variable) were assessed on MRI by expert physicians. We used multivariable regression models to evaluate the relationship between BMI and muscle atrophy while adjusting for age and sex in each study, conducted sensitivity analyses for full-thickness tear and combined results using inverse variance-weighted meta-analysis.ResultsA total of 539 patients (MOON=395, ROW=144) from the combined cohorts had MRI data available on muscle atrophy. Among these patients, 246 (46%) had atrophy of at least one of the muscles of the rotator cuff and 282 (52%) had full-thickness tears. In meta-analysis across both cohorts, each 5 kg/m2 increase in BMI was associated with a 21% (aOR=1.21, 95% CI=1.02, 1.43) increased odds of having muscle atrophy among individuals with any tear size, and 36% (aOR=1.36, 95% CI=1.01–1.81) increased odds among individuals with full-thickness tear. Conclusions Higher BMI was associated with significantly higher odds of muscle atrophy in patiens with rotator cuff tears. More study is needed to unders1tand why and how this relationship exists, as well as whether interventions to reduce BMI may help improve outcomes for these patients.Level of EvidenceIII.

Arthritis

Exercise

Obesity

Orthopedics

Pain

Pathology

Atrophy

Body mass index

Joint and ligament injuries

Muscle function

Patients

Range of motion

Rotator cuff

Shoulder

Surgical outcomes

Details

Title: Subtitle: Obesity is associated with muscle atrophy in rotator cuff tear
Creators: Simone Herzberg - Vanderbilt University
Zhiguo Zhao - Vanderbilt University Medical Center
Thomas Freeman - Great Lakes Environmental Center
Ravi Prakash
Keith Baumgarten - Orthopedic Institute
Julie Bishop - The Ohio State University
James Carey - University of Pennsylvania
Grant Jones - The Ohio State University
Eric McCarty - University of Colorado Denver
Edwin Spencer - Tennessee Orthopaedic Clinics
Armando Vidal - Steadman Philippon Research Institute
Nitin Jain - University of Michigan
Ayush Giri - Vanderbilt University Medical Center
John Kuhn - Vanderbilt University Medical Center
Michael Khazzam - The University of Texas Southwestern Medical Center
Elizabeth Matzkin - Brigham and Women's Hospital
Robert Brophy - Washington University in St. Louis
Warren Dunn - Texas Orthopedic Hospital
C Benjamin - University of California, San Francisco
Robert Marx - Hospital for Special Surgery
Sourav Poddar - University of Colorado Denver
Matthew Smith - Washington University in St. Louis
Brian Wolf - University of Iowa
Rick Wright - Vanderbilt University Medical Center
Resource Type: Journal article
Publication Details: BMJ Open Sport & Exercise Medicine, Vol.10(2), e001993
DOI: 10.1136/bmjsem-2024-001993
PMID: 38974096
PMCID: PMC11227827
NLM abbreviation: BMJ Open Sport Exerc Med
ISSN: 2055-7647
eISSN: 2055-7647
Publisher: BMJ Publishing Group LTD
Language: English
Date published: 06/01/2024
Academic Unit: Orthopedics and Rehabilitation; Physical Therapy and Rehabilitation Science
Record Identifier: 9984650260002771

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