Objective quantification of arm rigidity in MPTP-treated primates

Thomas O Mera; Matthew D Johnson; Darrin Rothe; Jianyu Zhang; Weidong Xu; Debabrata Ghosh; Jerrold Vitek; Jay L Alberts

doi:10.1016/j.jneumeth.2008.09.017

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Objective quantification of arm rigidity in MPTP-treated primates

Journal article

Peer reviewed

Objective quantification of arm rigidity in MPTP-treated primates

Thomas O Mera, Matthew D Johnson, Darrin Rothe, Jianyu Zhang, Weidong Xu, Debabrata Ghosh, Jerrold Vitek and Jay L Alberts

Journal of neuroscience methods, Vol.177(1), pp.20-29

2009

DOI: 10.1016/j.jneumeth.2008.09.017

PMCID: PMC2632780

PMID: 18930079

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http://doi.org/10.1016/j.jneumeth.2008.09.017View

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Abstract

Rigidity is a cardinal symptom of Parkinson's disease and is frequently used as an outcome measure in clinical and non-human primate studies examining the effects of medication or surgical intervention. A limitation of current rigidity assessment methods is that they are inherently subjective. To better understand the physiological mechanisms of rigidity and how various therapeutic approaches work, a more objective and quantitative method is needed. In this study, an automated arm rigidity testing (ART) system was developed to objectively quantify rigidity while the primate's limb was moved between two user-specified angles. Recordings of normal force versus elbow-angle were categorized according to area and slope. These quantitative measures of rigidity were investigated in three rhesus macaque monkeys treated with 1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine and compared with clinical assessment methods. The ART system incorporates electromyographical recordings that can detect and differentiate active from actual resistance. The ART system detected significant changes in rigidity measures following administration of apomorphine or deep brain stimulation of the globus pallidus internus. The most sensitive measures were total area, extension slope, and flexion slope. The ART system provides precise and reliable measures of rigidity that are objective and quantitative.

Parkinson's disease

Rigidity

MPTP

Deep brain stimulation

Apomorphine

Details

Title: Subtitle: Objective quantification of arm rigidity in MPTP-treated primates
Creators: Thomas O Mera - Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, United States
Matthew D Johnson - Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, United States
Darrin Rothe - Department of Electrical Engineering and Computer Science, Milwaukee School of Engineering, Milwaukee, WI, United States
Jianyu Zhang - Department of Neurosciences, Cleveland Clinic Foundation, Cleveland, OH, United States
Weidong Xu - Department of Neurosciences, Cleveland Clinic Foundation, Cleveland, OH, United States
Debabrata Ghosh - Department of Neurosciences, Cleveland Clinic Foundation, Cleveland, OH, United States
Jerrold Vitek - Department of Neurosciences, Cleveland Clinic Foundation, Cleveland, OH, United States
Jay L Alberts - Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, United States
Resource Type: Journal article
Publication Details: Journal of neuroscience methods, Vol.177(1), pp.20-29
DOI: 10.1016/j.jneumeth.2008.09.017
PMID: 18930079
PMCID: PMC2632780
NLM abbreviation: J Neurosci Methods
ISSN: 0165-0270
eISSN: 1872-678X
Publisher: Elsevier B.V
Language: English
Date published: 2009
Academic Unit: Iowa Neuroscience Institute; Anesthesia
Record Identifier: 9984006364902771

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