Journal article
Obstructive Sleep Apnea: A Risk Factor for Surgical Site Infection following Colectomy
Surgical infections, Vol.16(5), pp.611-617
10/01/2015
DOI: 10.1089/sur.2014.090
PMID: 26126118
Abstract
Background:
Obstructive sleep apnea (OSA) is associated with increased systemic oxidative stress, endothelial dysfunction, and activation of pro-inflammatory cascades, which increase host susceptibility to infection. OSA has not been evaluated as a risk factor for surgical site infection (SSI) following colectomy. We hypothesized that OSA increases the risk for SSI after colectomy.
Methods:
We performed a retrospective review of 507 colectomies that took place between August 2011 and September 2013. Forty-two patients carried the diagnosis of OSA prior to surgery. These 42 patients were matched to 68 patients with no OSA for age, body mass index (BMI), diabetes mellitus (DM), reason for surgery and surgical approach.
Results:
The rate of SSI was 28.6% (12 of 42) in the patients with and 10.3% (7 of 68) in the patients without OSA (p=0.03). Using logistic regression, the predictors of SSI following colectomy were found to be OSA (odds ratio [OR] of 3.98, 95% confidence interval [CI]=1.29–12.27), and DM (OR of 7.16, 95% CI=2.36–21.96). The average hospital stay after colectomy for patients with OSA complicated with SSI was 16.7 d whereas patients with OSA without SSI stayed 7.4 d (p<0.001). The rate of organ space infections was 9.5% (4 of 42) in the patients with OSA compared with 0 (p=0.02) in patients without OSA.
Conclusions:
OSA is an independent risk factor for SSI following colectomy. Patients with OSA have substantially greater rates of organ space SSI and longer hospital stay.
Details
- Title: Subtitle
- Obstructive Sleep Apnea: A Risk Factor for Surgical Site Infection following Colectomy
- Creators
- Spyridon Fortis - 2Department of Pulmonary and Critical Care, University of Minnesota, Minneapolis, MinnesotaKristin Pokorney Colling - 1Department of Surgery, University of Minnesota, Minneapolis, MinnesotaCatherine L Statz - 1Department of Surgery, University of Minnesota, Minneapolis, MinnesotaJames J Glover - 1Department of Surgery, University of Minnesota, Minneapolis, MinnesotaDavid M Radosevich - 1Department of Surgery, University of Minnesota, Minneapolis, MinnesotaGreg J Beilman - 1Department of Surgery, University of Minnesota, Minneapolis, Minnesota
- Resource Type
- Journal article
- Publication Details
- Surgical infections, Vol.16(5), pp.611-617
- Publisher
- Mary Ann Liebert, Inc
- DOI
- 10.1089/sur.2014.090
- PMID
- 26126118
- ISSN
- 1096-2964
- eISSN
- 1557-8674
- Language
- English
- Date published
- 10/01/2015
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
- Record Identifier
- 9984094344702771
Metrics
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