Obstructive sleep apnea and risk for late-life depression

Siddharth Bajpai; Kyoung Bin Im; Mark Eric Dyken; Simrit K Sodhi; Jess G Fiedorowicz

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Obstructive sleep apnea and risk for late-life depression

Journal article

Peer reviewed

Obstructive sleep apnea and risk for late-life depression

Siddharth Bajpai, Kyoung Bin Im, Mark Eric Dyken, Simrit K Sodhi and Jess G Fiedorowicz

Annals of clinical psychiatry, Vol.26(3), pp.163-170

08/2014

PMID: 24812654

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Abstract

Obstructive sleep apnea (OSA) is a sleep-related breathing disorder characterized by repetitive pharyngeal collapse. Because of the association between OSA, ischemia, and late-life depression, we hypothesized that older patients with OSA would have a higher prevalence of depression relative to their younger counterparts. We retrospectively reviewed charts of patients evaluated at the Sleep Disorders Center (SDC) at University of Iowa Hospitals and Clinics. A total of 617 patients age≥18 seen at SDC for diagnostic and therapeutic sleep studies were identified. Patients with a chart diagnosis of depressive disorder or treatment with antidepressants were identified as having a depressive disorder. Patients with an Apnea/Hypopnea Index≥5 were identified as having OSA. No evidence of an escalating prevalence of depression with age was found in patients with OSA relative to those without the disorder. Prevalence of depression was similar in the OSA and the nonapnea groups (40.9% vs 40.3%, respectively; χ2=0.02; df=1; P=.89). Individuals with OSA had a significantly higher body mass index and greater number of chart diagnoses of hypertension, diabetes mellitus, and coronary artery disease compared with the nonapnea group. The prevalence of depression among individuals with OSA does not appear to be moderated by age. Similarly high rates of depression were observed across the population of individuals referred for sleep studies, whether or not they were diagnosed with OSA.

Comorbidity

Prevalence

Age Factors

Humans

Middle Aged

Male

Gastroesophageal Reflux - epidemiology

Hyperlipidemias - epidemiology

Adult

Female

Iowa - epidemiology

Retrospective Studies

Sleep Apnea, Obstructive - epidemiology

Depressive Disorder - epidemiology

Hypertension - epidemiology

Body Mass Index

Severity of Illness Index

Risk Factors

Anxiety Disorders - epidemiology

Polysomnography

Diabetes Mellitus - epidemiology

Obesity - epidemiology

Aged

Coronary Artery Disease - epidemiology

Snoring - epidemiology

Details

Title: Subtitle: Obstructive sleep apnea and risk for late-life depression
Creators: Siddharth Bajpai
Kyoung Bin Im
Mark Eric Dyken
Simrit K Sodhi
Jess G Fiedorowicz
Resource Type: Journal article
Publication Details: Annals of clinical psychiatry, Vol.26(3), pp.163-170
Publisher: United States
PMID: 24812654
ISSN: 1040-1237
eISSN: 1547-3325
Grant note: 1K23MH083695-01A210 / NIMH NIH HHS
Language: English
Date published: 08/2014
Academic Unit: Neurology; Psychiatry; Epidemiology; Iowa Neuroscience Institute
Record Identifier: 9984071732402771

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6 Times Cited - Web of Science