Obstructive sleep apnea in idiopathic intracranial hypertension: comparison with matched population data

Matthew J Thurtell; Lynn Marie Trotti; Edward O Bixler; David B Rye; Donald L Bliwise; Nancy J Newman; Valérie Biousse; Beau B Bruce

doi:10.1007/s00415-013-6858-6

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Obstructive sleep apnea in idiopathic intracranial hypertension: comparison with matched population data

Journal article

Open access

Peer reviewed

Obstructive sleep apnea in idiopathic intracranial hypertension: comparison with matched population data

Matthew J Thurtell, Lynn Marie Trotti, Edward O Bixler, David B Rye, Donald L Bliwise, Nancy J Newman, Valérie Biousse and Beau B Bruce

Journal of neurology, Vol.260(7), pp.1748-1751

07/2013

DOI: 10.1007/s00415-013-6858-6

PMCID: PMC3707935

PMID: 23412355

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Abstract

Patients with idiopathic intracranial hypertension (IIH) frequently have coexisting obstructive sleep apnea (OSA). We aimed to determine if the prevalence and severity of OSA is greater in patients with IIH than would be expected, given their other risk factors for OSA. We included 24 patients (20 women, four men) with newly-diagnosed IIH who had undergone overnight polysomnography. We calculated the expected apnea-hypopnea index (AHI) for each patient, based on their age, sex, race, body mass index (BMI), and menopausal status, using a model derived from 1,741 randomly-sampled members of the general population who had undergone overnight polysomnography. We compared the AHI values obtained from polysomnography with those predicted by the model using a paired t test. Our study had 80 % power to detect a 10-unit change in mean AHI at α = 0.05. Eight patients (33.3 %; six women, two men) had OSA by polysomnography. AHIs from polysomnography were not significantly different from those predicted by the model (mean difference 3.5, 95 % CI: -3.0-9.9, p = 0.28). We conclude that the prevalence and severity of OSA in IIH patients is no greater than would be expected for their age, sex, race, BMI, and menopausal status. It remains unclear whether the presence or treatment of OSA influences the clinical course of IIH.

Body Mass Index

Severity of Illness Index

Sleep Apnea, Obstructive - physiopathology

Prevalence

Comorbidity

Humans

Middle Aged

Risk Factors

Male

Polysomnography

Pseudotumor Cerebri - physiopathology

Pseudotumor Cerebri - epidemiology

Adolescent

Sex Factors

Adult

Female

Sleep Apnea, Obstructive - epidemiology

Details

Title: Subtitle: Obstructive sleep apnea in idiopathic intracranial hypertension: comparison with matched population data
Creators: Matthew J Thurtell - Department of Ophthalmology, Emory University, Atlanta, GA, USA. mj.thurtell@gmail.com
Lynn Marie Trotti
Edward O Bixler
David B Rye
Donald L Bliwise
Nancy J Newman
Valérie Biousse
Beau B Bruce
Resource Type: Journal article
Publication Details: Journal of neurology, Vol.260(7), pp.1748-1751
DOI: 10.1007/s00415-013-6858-6
PMID: 23412355
PMCID: PMC3707935
NLM abbreviation: J Neurol
ISSN: 1432-1459
eISSN: 1432-1459
Publisher: Springer Science and Business Media LLC; Germany
Grant note: P30-EY06360 / NEI NIH HHS K23-EY019341 / NEI NIH HHS K23 EY019341 / NEI NIH HHS P30 EY006360 / NEI NIH HHS
Language: English
Date published: 07/2013
Academic Unit: Neurology; Ophthalmology and Visual Sciences
Record Identifier: 9983979974802771

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