Occupational Exposures and Subclinical Interstitial Lung Disease. The MESA (Multi-Ethnic Study of Atherosclerosis) Air and Lung Studies

Coralynn S Sack; Brent C Doney; Anna J Podolanczuk; Laura G Hooper; Noah S Seixas; Eric A Hoffman; Steven M Kawut; Sverre Vedal; Ganesh Raghu; R Graham Barr; David J Lederer; Joel D Kaufman

doi:10.1164/rccm.201612-2431OC

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Occupational Exposures and Subclinical Interstitial Lung Disease. The MESA (Multi-Ethnic Study of Atherosclerosis) Air and Lung Studies

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Occupational Exposures and Subclinical Interstitial Lung Disease. The MESA (Multi-Ethnic Study of Atherosclerosis) Air and Lung Studies

Coralynn S Sack, Brent C Doney, Anna J Podolanczuk, Laura G Hooper, Noah S Seixas, Eric A Hoffman, Steven M Kawut, Sverre Vedal, Ganesh Raghu, R Graham Barr, …

American journal of respiratory and critical care medicine, Vol.196(8), pp.1031-1039

10/15/2017

DOI: 10.1164/rccm.201612-2431OC

PMCID: PMC5649983

PMID: 28753039

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Abstract

The impact of a broad range of occupational exposures on subclinical interstitial lung disease (ILD) has not been studied. To determine whether occupational exposures to vapors, gas, dust, and fumes (VGDF) are associated with high-attenuation areas (HAA) and interstitial lung abnormalities (ILA), which are quantitative and qualitative computed tomography (CT)-based measurements of subclinical ILD, respectively. We performed analyses of participants enrolled in MESA (Multi-Ethnic Study of Atherosclerosis), a population-based cohort aged 45-84 years at recruitment. HAA was measured at baseline and on serial cardiac CT scans in 5,702 participants. ILA was ascertained in a subset of 2,312 participants who underwent full-lung CT scanning at 10-year follow-up. Occupational exposures were assessed by self-reported VGDF exposure and by job-exposure matrix (JEM). Linear mixed models and logistic regression were used to determine whether occupational exposures were associated with log-transformed HAA and ILA. Models were adjusted for age, sex, race/ethnicity, education, employment status, tobacco use, and scanner technology. Each JEM score increment in VGDF exposure was associated with 2.64% greater HAA (95% confidence interval [CI], 1.23-4.19%). Self-reported vapors/gas exposure was associated with an increased odds of ILA among those currently employed (1.76-fold; 95% CI, 1.09-2.84) and those less than 65 years old (1.97-fold; 95% CI, 1.16-3.35). There was no consistent evidence that occupational exposures were associated with progression of HAA over the follow-up period. JEM-assigned and self-reported exposures to VGDF were associated with measurements of subclinical ILD in community-dwelling adults.

Lung Diseases, Interstitial - etiology

Occupational Exposure - adverse effects

United States

Humans

Middle Aged

Occupational Diseases - etiology

Risk Factors

Logistic Models

Male

Pulmonary Disease, Chronic Obstructive - etiology

Air Pollutants, Occupational - adverse effects

Ethnic Groups

Aged, 80 and over

Female

Aged

Lung Diseases, Interstitial - epidemiology

Cohort Studies

Details

Title: Subtitle: Occupational Exposures and Subclinical Interstitial Lung Disease. The MESA (Multi-Ethnic Study of Atherosclerosis) Air and Lung Studies
Creators: Coralynn S Sack - 1 Division of Pulmonary and Critical Care, Department of Medicine, and
Brent C Doney - 2 Respiratory Health Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia
Anna J Podolanczuk - 3 Division of Pulmonary, Critical Care, and Allergy, Department of Medicine, Columbia University, New York, New York
Laura G Hooper - 1 Division of Pulmonary and Critical Care, Department of Medicine, and
Noah S Seixas - 4 Department of Environmental and Occupational Health, University of Washington, Seattle, Washington
Eric A Hoffman - 5 Division of Radiology, Department of Medicine, Carver School of Medicine, University of Iowa, Iowa City, Iowa; and
Steven M Kawut - 6 Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
Sverre Vedal - 4 Department of Environmental and Occupational Health, University of Washington, Seattle, Washington
Ganesh Raghu - 1 Division of Pulmonary and Critical Care, Department of Medicine, and
R Graham Barr - 3 Division of Pulmonary, Critical Care, and Allergy, Department of Medicine, Columbia University, New York, New York
David J Lederer - 3 Division of Pulmonary, Critical Care, and Allergy, Department of Medicine, Columbia University, New York, New York
Joel D Kaufman - 4 Department of Environmental and Occupational Health, University of Washington, Seattle, Washington
Resource Type: Journal article
Publication Details: American journal of respiratory and critical care medicine, Vol.196(8), pp.1031-1039
DOI: 10.1164/rccm.201612-2431OC
PMID: 28753039
PMCID: PMC5649983
NLM abbreviation: Am J Respir Crit Care Med
ISSN: 1073-449X
eISSN: 1535-4970
Publisher: United States
Grant note: N01HC95169 / NHLBI NIH HHS N01HC95161 / NHLBI NIH HHS T32 HL105323 / NHLBI NIH HHS N01HC95164 / NHLBI NIH HHS HHSN263201500003I / NIH HHS N01HC95167 / NHLBI NIH HHS RC1 HL100543 / NHLBI NIH HHS N01HC95159 / NHLBI NIH HHS R01 HL103676 / NHLBI NIH HHS N01HC95163 / NHLBI NIH HHS R01 HL077612 / NHLBI NIH HHS N01HC95166 / NHLBI NIH HHS K24 HL103844 / NHLBI NIH HHS UL1 TR001079 / NCATS NIH HHS P30 ES005605 / NIEHS NIH HHS R01 HL093081 / NHLBI NIH HHS T32 HL007287 / NHLBI NIH HHS HHSN268201500003C / NHLBI NIH HHS N01HC95160 / NHLBI NIH HHS R01 HL112986 / NHLBI NIH HHS T42 OH008433 / NIOSH CDC HHS UL1 TR000040 / NCATS NIH HHS N01HC95168 / NHLBI NIH HHS K24 HL131937 / NHLBI NIH HHS N01HC95165 / NHLBI NIH HHS N01HC95162 / NHLBI NIH HHS
Language: English
Date published: 10/15/2017
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
Record Identifier: 9984051784702771

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