Journal article
Occupational Pesticide Use and Risk of Renal Cell Carcinoma in the Agricultural Health Study
Environmental health perspectives, Vol.128(6), pp.67011-67011
06/2020
DOI: 10.1289/EHP6334
PMCID: PMC7292387
PMID: 32692250
Abstract
Agricultural work and occupational pesticide use have been associated with increased risk of renal cell carcinoma (RCC), the most common form of kidney cancer. However, few prospective studies have investigated links to specific pesticides.
We evaluated the lifetime use of individual pesticides and the incidence of RCC.
We evaluated the associations between intensity-weighted lifetime days (IWDs) of 38 pesticides and incident RCC in the Agricultural Health Study, a prospective cohort of licensed pesticide applicators in Iowa and North Carolina. Among 55,873 applicators, 308 cases were diagnosed between enrollment (1993-1997) and the end of follow-up (2014-2015). We estimated incidence rate ratios (RRs) and 95% confidence intervals (CIs) using Poisson regression, controlling for potential confounding factors, with lagged and unlagged pesticide exposures.
There was a statistically significant increased risk of RCC among the highest users of 2,4,5-T compared with never users [unlagged
(95% CI: 1.65, 5.17;
)], with similar risk estimates for lagged exposure [20-y lag
(95% CI: 1.83, 6.22;
)]. In 20-y lagged analyses, we also found exposure-response associations with chlorpyrifos [
(95% CI: 1.05, 2.70;
)], chlordane [
(95% CI: 1.10, 3.87;
)], atrazine [
(95% CI: 1.00, 2.03;
)], cyanazine [
(95% CI: 1.03, 2.50;
)], and paraquat [
(95% CI: 1.03, 3.70;
)].
This is, to our knowledge, the first prospective study to evaluate RCC risk in relation to various pesticides. We found evidence of associations with RCC for four herbicides (2,4,5-T, atrazine, cyanazine, and paraquat) and two insecticides (chlorpyrifos and chlordane). Our findings provide insights into specific chemicals that may influence RCC risk among pesticide applicators. Confirmation of these findings and investigations of the biologic plausibility and potential mechanisms underlying the observed associations are warranted. https://doi.org/10.1289/EHP6334.
Details
- Title: Subtitle
- Occupational Pesticide Use and Risk of Renal Cell Carcinoma in the Agricultural Health Study
- Creators
- Gabriella Andreotti - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Rockville, Maryland, USALaura E Beane Freeman - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Rockville, Maryland, USAJoseph J Shearer - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Rockville, Maryland, USACatherine C Lerro - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Rockville, Maryland, USAStella Koutros - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Rockville, Maryland, USAChristine G Parks - Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, North Carolina, USAAaron Blair - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Rockville, Maryland, USACharles F Lynch - State Health Registry of Iowa, Iowa City, Iowa, USAJay H Lubin - Biostatistics Branch, Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Rockville, Maryland, USADale P Sandler - Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, North Carolina, USAJonathan N Hofmann - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Rockville, Maryland, USA
- Resource Type
- Journal article
- Publication Details
- Environmental health perspectives, Vol.128(6), pp.67011-67011
- Publisher
- United States
- DOI
- 10.1289/EHP6334
- PMID
- 32692250
- PMCID
- PMC7292387
- ISSN
- 0091-6765
- eISSN
- 1552-9924
- Grant note
- P30 ES005605 / NIEHS NIH HHS Z01 CP010119 / Intramural NIH HHS P30 CA086862 / NCI NIH HHS
- Language
- English
- Date published
- 06/2020
- Academic Unit
- Epidemiology
- Record Identifier
- 9984066105902771
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