Occupational insecticide exposure and risk of non-Hodgkin lymphoma: A pooled case-control study from the InterLymph Consortium

Anneclaire J De Roos; Leah H Schinasi; Lucia Miligi; James R Cerhan; Parveen Bhatti; Andrea 't Mannetje; Dalsu Baris; Yolanda Benavente; Geza Benke; Jacqueline Clavel; Delphine Casabonne; Lin Fritschi; Jonathan N Hofmann; Tran Huynh; Alain Monnereau; Sara Piro; Susan L Slager; Claire M Vajdic; Sophia S Wang; Yawei Zhang; Leslie Bernstein; Pierluigi Cocco

doi:10.1002/ijc.33740

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Occupational insecticide exposure and risk of non-Hodgkin lymphoma: A pooled case-control study from the InterLymph Consortium

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Occupational insecticide exposure and risk of non-Hodgkin lymphoma: A pooled case-control study from the InterLymph Consortium

Anneclaire J De Roos, Leah H Schinasi, Lucia Miligi, James R Cerhan, Parveen Bhatti, Andrea 't Mannetje, Dalsu Baris, Yolanda Benavente, Geza Benke, Jacqueline Clavel, …

International journal of cancer, Vol.149(10), pp.1768-1786

11/15/2021

DOI: 10.1002/ijc.33740

PMCID: PMC10560384

PMID: 34270795

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Abstract

Evidence for the human health effects of pesticides is needed to inform risk assessment. We studied the relationship between occupational insecticide use and risk of non-Hodgkin lymphoma (NHL) by pooling data from nine case-control studies participating in the InterLymph Consortium, including 7909 cases and 8644 controls from North America, the European Union and Australia. Insecticide use was coded using self-report or expert assessment, for insecticide groups (eg, organophosphates, pyrethroids) and active ingredients (eg, malathion, permethrin). Associations with insecticides were estimated using logistic regression to produce odds ratios (ORs) and 95% confidence intervals (CI) for all NHL and NHL subtypes, with adjustment for study site, demographic factors and use of other pesticides. Occupational insecticide use, overall, was not associated with risk of NHL. Use of organophosphate insecticides was associated with increased risk of all NHL and the subtype follicular lymphoma, and an association was found with diazinon, in particular (ever use: OR = 2.05, 95%CI: 1.24-3.37). The carbamate insecticide, carbaryl, was associated with risk of all NHL, and the strongest associations were found with T-cell NHL for ever-use (OR = 2.44, 95%CI: 1.13-5.28) and longer duration (>8 years vs never: OR = 2.90, 95%CI: 1.02-8.25). There was no association of NHL with other broad groups of insecticides, including organochlorines and pyrethroids, and some inverse associations were estimated in relation to historical DDT use. Our findings contribute to the totality of evidence available to help inform risk decisions by public health and regulatory agencies of importance given continued, widespread use of organophosphate and carbamate insecticides.

Australia

European Union

North America

Adult

Aged

Case-Control Studies

Female

Humans

Insecticides - poisoning

Lymphoma, Non-Hodgkin - diagnosis

Lymphoma, Non-Hodgkin - etiology

Lymphoma, Non-Hodgkin - prevention & control

Male

Middle Aged

Occupational Diseases - diagnosis

Occupational Diseases - etiology

Occupational Diseases - prevention & control

Occupational Exposure - adverse effects

Occupational Exposure - analysis

Occupational Health - statistics & numerical data

Odds Ratio

Risk Assessment - methods

Risk Assessment - statistics & numerical data

Risk Factors

Details

Title: Subtitle: Occupational insecticide exposure and risk of non-Hodgkin lymphoma: A pooled case-control study from the InterLymph Consortium
Creators: Anneclaire J De Roos - Drexel University
Leah H Schinasi - Drexel University
Lucia Miligi - Florence (Netherlands)
James R Cerhan - Mayo Clinic
Parveen Bhatti - University of British Columbia
Andrea 't Mannetje - Massey University
Dalsu Baris - University of Minnesota
Yolanda Benavente - Instituto de Salud Carlos III
Geza Benke - Monash University
Jacqueline Clavel - Délégation Paris 5
Delphine Casabonne - Instituto de Salud Carlos III
Lin Fritschi - Monash University
Jonathan N Hofmann - National Cancer Institute
Tran Huynh - Drexel University
Alain Monnereau - Université de Bordeaux
Sara Piro - Florence (Netherlands)
Susan L Slager - Mayo Clinic
Claire M Vajdic - UNSW Sydney
Sophia S Wang - City Of Hope National Medical Center
Yawei Zhang - National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing, China
Leslie Bernstein - City Of Hope National Medical Center
Pierluigi Cocco - University of Manchester
Resource Type: Journal article
Publication Details: International journal of cancer, Vol.149(10), pp.1768-1786
DOI: 10.1002/ijc.33740
PMID: 34270795
PMCID: PMC10560384
NLM abbreviation: Int J Cancer
ISSN: 0020-7136
eISSN: 1097-0215
Grant note: R03 CA199515 / NCI NIH HHS R03CA199515 / National Cancer Institute (NCI) of the National Institutes of Health (NIH) R01CA92153 / National Cancer Institute (NCI) of the National Institutes of Health (NIH) P50CA97274 / National Cancer Institute (NCI) of the National Institutes of Health (NIH)
Language: English
Date published: 11/15/2021
Academic Unit: Epidemiology
Record Identifier: 9984368097402771

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