Occurrence and predictors of patient reported fertility discussions in non-Hodgkin lymphoma patients: utilizing the lymphoma epidemiology of outcomes (LEO) cohort study

Nadia Toumeh; Melissa Larson; Brianna Negaard; Carla Casulo; Sairah Ahmed; Matthew Maurer; Andrew Feldman; Eric Mou; Jonathon Cohen; Thomas Habermann; Dai Chihara; Izidore S Lossos; Jonathan Friedberg; Brad Kahl; Peter Martin; Christopher R Flowers; James R Cerhan; AnnaLynn M Williams; Allison Rosenthal; Ali Ainsworth; Carrie Thompson; Urshila Durani

doi:10.1080/10428194.2025.2582721

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Occurrence and predictors of patient reported fertility discussions in non-Hodgkin lymphoma patients: utilizing the lymphoma epidemiology of outcomes (LEO) cohort study

Journal article

Peer reviewed

Occurrence and predictors of patient reported fertility discussions in non-Hodgkin lymphoma patients: utilizing the lymphoma epidemiology of outcomes (LEO) cohort study

Nadia Toumeh, Melissa Larson, Brianna Negaard, Carla Casulo, Sairah Ahmed, Matthew Maurer, Andrew Feldman, Eric Mou, Jonathon Cohen, Thomas Habermann, …

Leukemia & lymphoma, Vol.67(1), pp.190-197

01/02/2026

DOI: 10.1080/10428194.2025.2582721

PMID: 41178593

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Abstract

Patients with non-Hodgkin lymphoma (NHL), especially younger individuals, can face fertility risks from treatment. We assessed rates and predictors of fertility counseling and preservation in this population. The LEO cohort prospectively enrolled newly diagnosed NHL patients (2015-2020) at eight U.S. academic centers. We assessed responses to a 3-year survivorship questionnaire in those aged 18-50 at diagnosis; logistic regression evaluated predictors of fertility counseling. Of 77 respondents included (46% female, median age 40), 72.2% of females and 58.5% of males recalled having a fertility discussion at diagnosis. Fertility counseling was more likely to occur in those aged 18-39 versus 40-50 (OR 10.2, 95% CI 3.3-39.2) and in those receiving alkylating therapy (OR 9.0, 95% CI 2.3-45.5). Interventions are still needed to ensure adequate survivorship care.

patient outcomes

fertility preservation

Lymphoma

fertility

Details

Title: Subtitle: Occurrence and predictors of patient reported fertility discussions in non-Hodgkin lymphoma patients: utilizing the lymphoma epidemiology of outcomes (LEO) cohort study
Creators: Nadia Toumeh - Mayo Clinic in Arizona
Melissa Larson - Mayo Clinic in Florida
Brianna Negaard - Mayo Clinic in Florida
Carla Casulo - University of Rochester
Sairah Ahmed - The University of Texas MD Anderson Cancer Center
Matthew Maurer - Mayo Clinic in Florida
Andrew Feldman - Mayo Clinic in Arizona
Eric Mou - University of Iowa
Jonathon Cohen - Emory University
Thomas Habermann - Mayo Clinic in Arizona
Dai Chihara - The University of Texas MD Anderson Cancer Center
Izidore S Lossos - Sylvester Comprehensive Cancer Center
Jonathan Friedberg - University of Rochester
Brad Kahl - Washington University in St. Louis
Peter Martin - Cornell University
Christopher R Flowers - The University of Texas MD Anderson Cancer Center
James R Cerhan - Mayo Clinic in Florida
AnnaLynn M Williams - University of Rochester
Allison Rosenthal - Mayo Clinic Hospital
Ali Ainsworth - Mayo Clinic
Carrie Thompson - Mayo Clinic in Arizona
Urshila Durani - Mayo Clinic in Arizona
Resource Type: Journal article
Publication Details: Leukemia & lymphoma, Vol.67(1), pp.190-197
DOI: 10.1080/10428194.2025.2582721
PMID: 41178593
NLM abbreviation: Leuk Lymphoma
ISSN: 1042-8194
eISSN: 1029-2403
Publisher: Taylor & Francis
Grant note: Lymphoma Epidemiology of Outcomes (LEO) Cohort Study: U01 CA195568
Grant U01 CA195568 (The Lymphoma Epidemiology of Outcomes (LEO) Cohort Study).
Language: English
Electronic publication date: 11/03/2025
Date published: 01/02/2026
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Epidemiology; Internal Medicine
Record Identifier: 9985024139602771

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