Occurrence of Vascular Lake Phenomenon as a Predictor of Improved Tumor Response in HCC Patients That Underwent DEB-TACE

Rafael Noronha Cavalcante; Felipe Nasser; Joaquim M. Motta-Leal-Filho; Breno B. Affonso; Francisco L. Galastri; Bruna De Fina; Rodrigo G. Garcia; Nelson Wolosker

doi:10.1007/s00270-017-1678-1

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Occurrence of Vascular Lake Phenomenon as a Predictor of Improved Tumor Response in HCC Patients That Underwent DEB-TACE

Journal article

Peer reviewed

Occurrence of Vascular Lake Phenomenon as a Predictor of Improved Tumor Response in HCC Patients That Underwent DEB-TACE

Rafael Noronha Cavalcante, Felipe Nasser, Joaquim M. Motta-Leal-Filho, Breno B. Affonso, Francisco L. Galastri, Bruna De Fina, Rodrigo G. Garcia and Nelson Wolosker

Cardiovascular and interventional radiology, Vol.40(7), pp.1044-1051

07/01/2017

DOI: 10.1007/s00270-017-1678-1

PMID: 28500458

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Abstract

Purpose To evaluate incidence and predictive factors for the vascular lake phenomenon (VLP), as well as to compare local and overall tumor response in patients with and without VLP induced during DEB-TACE for HCC. Methods A total of 200 consecutive patients with 323 HCC nodules underwent first-session DEB-TACE from 2011 to 2014. Patients were divided in two groups, according to the presence of the VLP during DEB-TACE. Pre-and post-treatment imaging studies (CT or MRI) were performed. Primary endpoint was assessment of tumor response, evaluated by mRECIST. Comparison of response rates between the VLP group and the non-VLP group was performed. Secondary endpoints were the determination of incidence rate and predictive factors for the VLP. Results The VLP was observed in 39/323 (12.1%) of the nodules treated. At multivariate logistic regression analysis, tumor size >= 3 cm in diameter (OR 13.95; 95% CI 3.60-54.05), presence of a pseudocapsule (OR 6.67; 95% CI 1.45-30.59) and alpha-fetoprotein levels (OR 1.004; 95% CI 1.000-1.007) remained predictive for the VLP occurrence. On a nodule-based analysis (p < 0.001), target lesion response analysis (p = 0.003) and overall response analysis (p = 0.004) the VLP group presented a higher objective response rate than the non-VLP group. Conclusion VLP is observed in 12% of the patients and happens more frequently in large and encapsulated tumors. It seems to be associated with better local and overall responses in HCC patients who underwent DEB-TACE.

Cardiac & Cardiovascular Systems

Cardiovascular System & Cardiology

Life Sciences & Biomedicine

Radiology, Nuclear Medicine & Medical Imaging

Science & Technology

Details

Title: Subtitle: Occurrence of Vascular Lake Phenomenon as a Predictor of Improved Tumor Response in HCC Patients That Underwent DEB-TACE
Creators: Rafael Noronha Cavalcante - Hospital Israelita Albert Einstein
Felipe Nasser - Hospital Israelita Albert Einstein
Joaquim M. Motta-Leal-Filho - Albert Einstein College of Medicine
Breno B. Affonso - Hospital Israelita Albert Einstein
Francisco L. Galastri - Hospital Israelita Albert Einstein
Bruna De Fina - Hospital Israelita Albert Einstein
Rodrigo G. Garcia - Hospital Israelita Albert Einstein
Nelson Wolosker - Hospital Israelita Albert Einstein
Resource Type: Journal article
Publication Details: Cardiovascular and interventional radiology, Vol.40(7), pp.1044-1051
DOI: 10.1007/s00270-017-1678-1
PMID: 28500458
NLM abbreviation: Cardiovasc Intervent Radiol
ISSN: 0174-1551
eISSN: 1432-086X
Publisher: Springer Nature
Number of pages: 8
Language: English
Date published: 07/01/2017
Academic Unit: Radiology
Record Identifier: 9985180932202771

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