Octreotide and cholecystokinin antagonist reduce edema in obstruction-induced acute pancreatitis

Y Toriumi; I Samuel; D P Wilcockson; C M Turkelson; T E Solomon; R J Joehl

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Octreotide and cholecystokinin antagonist reduce edema in obstruction-induced acute pancreatitis

Journal article

Peer reviewed

Octreotide and cholecystokinin antagonist reduce edema in obstruction-induced acute pancreatitis

Y Toriumi, I Samuel, D P Wilcockson, C M Turkelson, T E Solomon and R J Joehl

The Journal of laboratory and clinical medicine, Vol.122(4), pp.450-454

10/1993

PMID: 8228560

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Abstract

Obstruction-induced acute pancreatitis in rats is associated with increased plasma cholecystokinin (CCK) levels. Duodenal replacement of bile reduces severity of pancreatitis and limits CCK increase. We investigated the role of CCK in the pathogenesis of obstruction-induced acute pancreatitis by pretreating rats with the somatostatin analog octreotide and the CCK antagonist L-364,718. Octreotide inhibits duodenal CCK release, and L-364,718 competitively blocks CCK receptors. We studied 31 rats after (1) sham operation (n = 7), (2) bile and pancreatic duct obstruction (BPDO) (n = 12), (3) BPDO plus octreotide (20 micrograms/kg IP and then 5 micrograms/kg/hr IV) (n = 6), and (4) BPDO plus L-364,718 (1 mg/kg IP and then 0.25 mg/kg/hr IV) (n = 6). Rats were killed after 18 hours. Pancreas weight, acute pancreatitis histology score, and plasma amylase and CCK levels were determined. Octreotide and L-364,718 limited the increase in pancreas weight. Octreotide also limited the rise in plasma CCK levels. These findings suggest that CCK may play a role in the pathogenesis of obstruction-induced acute pancreatitis.

Edema

Acute Disease

Benzodiazepinones - pharmacology

Pancreatic Ducts

Pancreas - drug effects

Pancreas - pathology

Rats

Male

Cholecystokinin - antagonists & inhibitors

Devazepide

Pancreatitis - drug therapy

Octreotide - therapeutic use

Octreotide - pharmacology

Rats, Sprague-Dawley

Animals

Analysis of Variance

Bile Ducts

Pancreatitis - pathology

Benzodiazepinones - therapeutic use

Details

Title: Subtitle: Octreotide and cholecystokinin antagonist reduce edema in obstruction-induced acute pancreatitis
Creators: Y Toriumi - Surgical and Research Services, Veterans Affairs Lakeside Medical Center, Chicago, IL 60611
I Samuel
D P Wilcockson
C M Turkelson
T E Solomon
R J Joehl
Resource Type: Journal article
Publication Details: The Journal of laboratory and clinical medicine, Vol.122(4), pp.450-454
PMID: 8228560
NLM abbreviation: J Lab Clin Med
ISSN: 0022-2143
eISSN: 1532-6543
Publisher: Elsevier; United States
Language: English
Date published: 10/1993
Academic Unit: Surgery
Record Identifier: 9984051534602771

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