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Oculodentodigital dysplasia syndrome associated with abnormal cerebral white matter
Journal article   Peer reviewed

Oculodentodigital dysplasia syndrome associated with abnormal cerebral white matter

David H Gutmann, Elaine H Zackai, Donna M McDonald‐McGinn, Kenneth H Fischbeck and John Kamholz
American journal of medical genetics, Vol.41(1), pp.18-20
10/01/1991
DOI: 10.1002/ajmg.1320410106
PMID: 1659191

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Abstract

Oculodentodigital dysplasia (ODDD) syndrome is an uncommon inherited disorder with eye and facial abnormalities, syndactyly, and defects in tooth enamel. Some of the previously reported patients with ODDD syndrome also manifested spastic quadriparesis. We describe a patient with sporadic ODDD syndrome referred for evaluation of progressive spastic paraparesis. Magnetic resonance imaging of the brain demonstrated abnormal white matter, which suggests an explanation for the observed spastic paraparesis.
hereditary spastic paraparesis leukodystrophy

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