Journal article
Odor detection, learning, and memory in Huntington's disease
Journal of the International Neuropsychological Society, Vol.5(7), pp.609-615
11/1999
DOI: 10.1017/S1355617799577035
PMID: 10645703
Abstract
We compared 7 mildly affected Huntington's
disease (HD) patients to 7 age- and education-matched healthy
controls (NC) on an odor detection test, the California
Odor Learning Test, and the California Verbal Learning
Test. Results demonstrated that odor detection sensitivity,
but not group membership, accounted for significant variance
in total olfactory learning. Both groups learned fewer
items in the olfactory modality compared to the verbal
modality, but retained a similar amount following a delay.
No group differences were demonstrated for verbal recognition
discriminability, but the HD group demonstrated significantly
impaired odor recognition discriminability. Finally, odor
detection provided excellent classification sensitivity
and specificity between the patients and controls, suggesting
that olfactory testing may provide a sensitive measure
of the early disease process in HD. (JINS, 1999,
5, 609–615.)
Details
- Title: Subtitle
- Odor detection, learning, and memory in Huntington's disease
- Creators
- JOANNE M HAMILTON - San Diego State University/University of California, San Diego, Joint Doctoral Program in Clinical PsychologyCLAIRE MURPHY - San Diego State University/University of California, San Diego, Joint Doctoral Program in Clinical PsychologyJANE S PAULSEN - University of California, San Diego and San Diego Veterans Affairs Medical Center
- Resource Type
- Journal article
- Publication Details
- Journal of the International Neuropsychological Society, Vol.5(7), pp.609-615
- Publisher
- Cambridge University Press
- DOI
- 10.1017/S1355617799577035
- PMID
- 10645703
- ISSN
- 1355-6177
- eISSN
- 1469-7661
- Number of pages
- 7
- Language
- English
- Date published
- 11/1999
- Academic Unit
- Psychiatry; Psychological and Brain Sciences
- Record Identifier
- 9984083822802771
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