Journal article
Off-resonance proton T1rho dispersion imaging of 17O-enriched tissue phantoms
Magnetic resonance in medicine, Vol.39(4), pp.588-595
04/1998
DOI: 10.1002/mrm.1910390412
PMID: 9543421
Abstract
Proton T1rho dispersion imaging is a recently described method for indirect detection of 17O. However, clinical implementation of this technique is hindered by the requirement for a high-amplitude spin-locking field (gammaB1 > 1 kHz) that exceeds current limitations in specific absorption rate (SAR). Here, a strategy is offered for circumventing high SAR in T1rho dispersion imaging of 17O through the use of low-amplitude off-resonance spin-locking pulses (gammaB1 < 300 Hz). Proton spin-lattice relaxation times in the off-resonance rotating frame were measured in H2(17)O-enriched tissue phantoms. On- and off-resonance T1rho dispersion imaging was implemented at 2 T using a spin-locking preparatory pulse cluster appended to a standard spin-echo sequence. On- and off-resonance dispersion images exhibited similar 17O-based image contrast. Magnetization transfer effects did not depend on 17O concentration and had no effect on image contrast. In conclusion, off-resonance proton T1rho dispersion imaging shows promise as a safe, sensitive technique for generating 17O-based T1rho contrast without exceeding SAR limitations.
Details
- Title: Subtitle
- Off-resonance proton T1rho dispersion imaging of 17O-enriched tissue phantoms
- Creators
- Sridhar R Charagundla - Department of Radiology, University of Pennsylvania, Philadelphia 19104-6100, USAAlan H StolpenJohn S LeighRavinder Reddy
- Resource Type
- Journal article
- Publication Details
- Magnetic resonance in medicine, Vol.39(4), pp.588-595
- Publisher
- United States
- DOI
- 10.1002/mrm.1910390412
- PMID
- 9543421
- ISSN
- 0740-3194
- eISSN
- 1522-2594
- Grant note
- 5T32-GM07170 / NIGMS NIH HHS RR02305 / NCRR NIH HHS R29-NS35625 / NINDS NIH HHS
- Language
- English
- Date published
- 04/1998
- Academic Unit
- Radiology; Internal Medicine
- Record Identifier
- 9984051702102771
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