Journal article
Older and Black Breast Cancer Survivors at Higher Risk for Negative Respiratory Outcomes Following COVID-19 Infection
Western journal of nursing research, Vol.47(11), pp.1075-1083
11/2025
DOI: 10.1177/01939459251366356
PMID: 40910577
Abstract
Negative respiratory outcomes have been reported in people diagnosed with COVID-19. Breast cancer, the most common cancer diagnosed in women globally, is an important cancer to investigate regarding COVID-19 outcomes. We hypothesized that women with breast cancer and infected with COVID-19 would demonstrate a greater risk for negative respiratory outcomes than people without breast cancer.
We sought to examine associations between breast cancer diagnosis, COVID-19 infection, and negative respiratory outcomes using an Oracle Real World dataset.
Horn and Gassaway's Practice-Based Evidence Framework structured this retrospective cohort study. Regression analysis identified associations among negative respiratory outcomes and breast cancer and COVID-19 diagnosis. Associations between preexisting comorbidities and COVID-19 infection complications in the dataset were also examined.
Breast cancer and COVID-19 diagnoses significantly predict increased odds of developing a negative respiratory outcome (OR = 1.11, CI 1.01-1.23,
= .03). Additional predictors of negative respiratory outcomes include advanced age (OR = 4.88, CI 4.21-5.65,
< .001); Black race (OR = 1.19, CI 1.11-1.28,
< .001); history of emergency department visits (OR = 1.33, CI 1.27-1.40,
< .001); and history of respiratory illness (OR = 2.60, CI 2.41-2.81,
< .001). Race/ethnicity (Asian or Hispanic), age 20 to 34, and pre-index ischemic stroke or atrial fibrillation were not significantly associated with increased odds of negative respiratory outcomes.
Black and older women with breast cancer are at increased risk of developing negative respiratory outcomes following a COVID-19 infection compared to younger and White women with breast cancer. Implications for clinical practice are discussed.
Details
- Title: Subtitle
- Older and Black Breast Cancer Survivors at Higher Risk for Negative Respiratory Outcomes Following COVID-19 Infection
- Creators
- Elizabeth A Anderson - University of MissouriAllison B Anbari - University of MissouriWilliam I Baskett - University of MissouriJennifer M Hulett - University of MissouriNatasayakarn Narkthong - Prince of Songkla UniversityAn-Lin Cheng - University of Missouri–Kansas CityNathan C Armer - University of MissouriYuanlu Sun - University of IowaChi-Ren Shyu - University of MissouriJane M Armer - University of Missouri
- Resource Type
- Journal article
- Publication Details
- Western journal of nursing research, Vol.47(11), pp.1075-1083
- DOI
- 10.1177/01939459251366356
- PMID
- 40910577
- NLM abbreviation
- West J Nurs Res
- ISSN
- 0193-9459
- eISSN
- 1552-8456
- Publisher
- Sage
- Grant note
- Washington University St. Louis Institute for Clinical and Translational Sciences: 15-21-030
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was funded through a grant from Washington University St. Louis Institute for Clinical and Translational Sciences (15-21-030).
- Language
- English
- Electronic publication date
- 09/05/2025
- Date published
- 11/2025
- Academic Unit
- Nursing
- Record Identifier
- 9984958288202771
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