Journal article
Oleamide modulates memory in rats
Neuroscience letters, Vol.313(1), pp.61-64
11/02/2001
DOI: 10.1016/S0304-3940(01)02256-X
PMID: 11684340
Abstract
Oleamide is a recently described lipid, obtained from the cerebrospinal fluid of sleep-deprived cats. It has been observed that oleamide possesses several biological effects, such as sleep induction, and immunological suppression as well as serotonin and gamma-aminobutyric acid receptors activation. In addition, oleamide also binds to the cannabinoid receptors. In this study, we have observed that oleamide facilitates memory extinction in a passive avoidance paradigm, reduces core temperature and pain perception, but does not affect significantly locomotion. These results suggest that oleamide modulates memory processes. However, we do not know if oleamide impairs the retrieval of the memory associated to the ‘not go’ behavior, or facilitates the fast re-learning of the ‘go’ behavior. In addition, since these effects are also induced by marijuana and anandamide, it is very likely that oleamide may be affecting the cerebral cannabinoid system to induce its effects.
Details
- Title: Subtitle
- Oleamide modulates memory in rats
- Creators
- Eric Murillo-Rodrı́guez - Universidad Nacional Autónoma de MéxicoMagda Giordano - Universidad Nacional Autónoma de MéxicoRafael Cabeza - The University of Texas at El PasoSteve J Henriksen - Department of Neuropharmacology, TSRI, La Jolla, CA, USAMónica Méndez Dı́az - Universidad Nacional Autónoma de MéxicoLuz Navarro - Universidad Nacional Autónoma de MéxicoOscar Prospéro-Garcı́a - Universidad Nacional Autónoma de México
- Resource Type
- Journal article
- Publication Details
- Neuroscience letters, Vol.313(1), pp.61-64
- Publisher
- Elsevier Ireland Ltd
- DOI
- 10.1016/S0304-3940(01)02256-X
- PMID
- 11684340
- ISSN
- 0304-3940
- eISSN
- 1872-7972
- Language
- English
- Date published
- 11/02/2001
- Academic Unit
- Molecular Physiology and Biophysics
- Record Identifier
- 9984695684902771
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