Olfactory bulbectomy attenuates cardiovascular sympathoexcitatory reflexes in rats

Julia A Moffitt; Angela J Grippo; Philip V Holmes; Alan Kim Johnson

doi:10.1152/ajpheart.00164.2002

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Olfactory bulbectomy attenuates cardiovascular sympathoexcitatory reflexes in rats

Journal article

Peer reviewed

Olfactory bulbectomy attenuates cardiovascular sympathoexcitatory reflexes in rats

Julia A Moffitt, Angela J Grippo, Philip V Holmes and Alan Kim Johnson

American journal of physiology. Heart and circulatory physiology, Vol.283(6), pp.H2575-2583

12/2002

DOI: 10.1152/ajpheart.00164.2002

PMID: 12388291

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Abstract

Bilateral removal of the olfactory lobes in rats produces a number of behavioral, endocrine, and neurochemical alterations in the brain. Little is known, however, regarding the effects of this treatment on cardiovascular function and autonomic reflexes. Male Sprague-Dawley rats underwent bilateral surgical ablation of the olfactory bulbs (n = 10) or were sham operated (n = 8). After 3 wk of recovery, animals were instrumented with femoral catheters and a lumbar sympathetic nerve recording electrode. After 24 h of recovery, cardiovascular responses to arterial baroreflex manipulation, air jet stress, and smoke exposure were recorded. Olfactory bulbectomized rats demonstrated attenuated sympathoexcitatory responses to hypotension, air jet stress, and smoke exposure, as well as elevated basal blood pressure, compared with sham-operated rats. These data indicate that the integrity of the olfactory bulbs in rats is important for the elicitation of normal cardiovascular and autonomic responses to a number of evocative stimuli.

Animals

Baroreflex - physiology

Blood Pressure - drug effects

Blood Pressure - physiology

Cardiovascular System - innervation

Catheterization

Electrodes, Implanted

Ganglionic Blockers - pharmacology

Heart Rate - physiology

Lumbosacral Region

Male

Neurosurgical Procedures

Olfactory Bulb - physiology

Olfactory Bulb - surgery

Rats

Rats, Sprague-Dawley

Reflex, Abnormal - physiology

Smoke - adverse effects

Stress, Physiological

Sympathetic Nervous System - physiology

Synaptic Transmission - physiology

Details

Title: Subtitle: Olfactory bulbectomy attenuates cardiovascular sympathoexcitatory reflexes in rats
Creators: Julia A Moffitt - The Cardiovascular Center, Iowa City, Iowa 52242, USA
Angela J Grippo
Philip V Holmes
Alan Kim Johnson
Resource Type: Journal article
Publication Details: American journal of physiology. Heart and circulatory physiology, Vol.283(6), pp.H2575-2583
DOI: 10.1152/ajpheart.00164.2002
PMID: 12388291
ISSN: 0363-6135
eISSN: 1522-1539
Grant note: HL-07121 / NHLBI NIH HHS HL-14388 / NHLBI NIH HHS HL-57472 / NHLBI NIH HHS
Language: English
Date published: 12/2002
Academic Unit: Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
Record Identifier: 9984213426302771

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