Journal article
Oligoclonal Bands in Multiple System Atrophy: Case Report and Proposed Mechanisms of Immunogenicity
Frontiers in neuroscience, Vol.16, 852939
02/28/2022
DOI: 10.3389/fnins.2022.852939
PMCID: PMC8919426
PMID: 35295090
Abstract
Multiple System Atrophy (MSA) is a neurodegenerative disease with heterogeneous manifestations and is therefore difficult to diagnose definitively. Because of this, oftentimes an extensive workup for mimickers is undertaken. We herein report a case where the history and cerebrospinal fluid (CSF) findings of oligoclonal bands suggested an inflammatory disorder. Immunomodulatory therapy failed to ameliorate symptoms or alter the trajectory of continued physical decline, prompting re-visitation of the diagnosis. Oligoclonal bands, while generally viewed as specific to multiple sclerosis or other inflammatory conditions, may be seen in other disease processes. Therefore, this finding should not exclude consideration of neurodegenerative disease.
Details
- Title: Subtitle
- Oligoclonal Bands in Multiple System Atrophy: Case Report and Proposed Mechanisms of Immunogenicity
- Creators
- Lee E. Neilson - Oregon Health & Science UniversityChristopher Hollen - Oregon Health & Science UniversityAmie Hiller - Oregon Health & Science UniversityLindsey Wooliscroft - Oregon Health & Science University
- Resource Type
- Journal article
- Publication Details
- Frontiers in neuroscience, Vol.16, 852939
- DOI
- 10.3389/fnins.2022.852939
- PMID
- 35295090
- PMCID
- PMC8919426
- NLM abbreviation
- Front Neurosci
- ISSN
- 1662-4548
- eISSN
- 1662-453X
- Grant note
- K23HD101667 / Office of Extramural Research, National Institutes of Health (100006955) K23HD101667 / Office of Research Infrastructure Programs, National Institutes of Health (100016958) VA Parkinson’s Disease Research, Education and Clinical Centers K23HD101667 / Center for Information Technology (100000093) K23HD101667 / Center for Scientific Review (100005440) U.S. Department of Veterans Affairs (http://data.elsevier.com/vocabulary/SciValFunders/100000738) National Institutes of Health (http://data.elsevier.com/vocabulary/SciValFunders/100000002) PADRECC K23HD101667 / National Institute of Child Health and Human Development (http://data.elsevier.com/vocabulary/SciValFunders/100000071) National Center for Medical Rehabilitation Research (http://data.elsevier.com/vocabulary/SciValFunders/100006937)
- Language
- English
- Date published
- 02/28/2022
- Academic Unit
- Neurology
- Record Identifier
- 9985089125502771
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