Journal article
Oligodendrocytes that survive acute coronavirus infection induce prolonged inflammatory responses in the CNS
Proceedings of the National Academy of Sciences - PNAS, Vol.117(27), pp.15902-15910
07/07/2020
DOI: 10.1073/pnas.2003432117
PMCID: PMC7355048
PMID: 32571951
Abstract
Neurotropic strains of mouse hepatitis virus (MHV), a coronavirus, cause acute and chronic demyelinating encephalomyelitis with similarities to the human disease multiple sclerosis. Here, using a lineage-tracking system, we show that some cells, primarily oligodendrocytes (OLs) and oligodendrocyte precursor cells (OPCs), survive the acute MHV infection, are associated with regions of demyelination, and persist in the central nervous system (CNS) for at least 150 d. These surviving OLs express major histocompatibility complex (MHC) class I and other genes associated with an inflammatory response. Notably, the extent of inflammatory cell infiltration was variable, dependent on anatomic location within the CNS, and without obvious correlation with numbers of surviving cells. We detected more demyelination in regions with larger numbers of T cells and microglia/macrophages compared to those with fewer infiltrating cells. Conversely, in regions with less inflammation, these previously infected OLs more rapidly extended processes, consistent with normal myelinating function. Together, these results show that OLs are inducers as well as targets of the host immune response and demonstrate how a CNS infection, even after resolution, can induce prolonged inflammatory changes with CNS region-dependent impairment in remyelination.
Details
- Title: Subtitle
- Oligodendrocytes that survive acute coronavirus infection induce prolonged inflammatory responses in the CNS
- Creators
- Ruangang Pan - Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242Qinran Zhang - School of Mathematics and Statistics, Wuhan University, 430072 Wuhan, ChinaScott M Anthony - Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242Yu Zhou - School of Mathematics and Statistics, Wuhan University, 430072 Wuhan, ChinaXiufen Zou - School of Mathematics and Statistics, Wuhan University, 430072 Wuhan, ChinaMartin Cassell - Department of Anatomy and Cell Biology, University of Iowa, Iowa City, IA 52242Stanley Perlman - Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242; stanley-perlman@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, Vol.117(27), pp.15902-15910
- DOI
- 10.1073/pnas.2003432117
- PMID
- 32571951
- PMCID
- PMC7355048
- NLM abbreviation
- Proc Natl Acad Sci U S A
- ISSN
- 0027-8424
- eISSN
- 1091-6490
- Publisher
- National Academy of Sciences; United States
- Grant note
- R01 NS036592 / NINDS NIH HHS
- Language
- English
- Date published
- 07/07/2020
- Academic Unit
- Microbiology and Immunology; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Pathology; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
- Record Identifier
- 9984070893702771
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