Journal article
Oligonucleotide-based strategies to reduce gene expression
Differentiation (London), Vol.69(2), pp.75-82
2001
DOI: 10.1046/j.1432-0436.2001.690201.x
PMID: 11798068
Abstract
Research on embryonic development and differentiation provides a sensitive, but challenging opportunity to use a variety of techniques designed to modulate gene expression. Changes in the expression of a single gene can alter levels of other genes and provide information on developmentally regulated gene expression pathways. The morphological consequences of altered gene expression can link gene expression to developmental fate. Oligonucleotide-based approaches offer a variety of means to potentially disrupt normal gene expression. The basis for some of these approaches is presented in this review.
Details
- Title: Subtitle
- Oligonucleotide-based strategies to reduce gene expression
- Creators
- John M Dagle - Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA: Tel: +1 319 335 7918, Fax: +1 319 335 9570Daniel L Weeks - Department of Biochemistry, University of Iowa, Iowa City, Iowa 52242, USA: Tel: +1 319 335 7918, Fax: +1 319 335 9570
- Resource Type
- Journal article
- Publication Details
- Differentiation (London), Vol.69(2), pp.75-82
- Publisher
- Elsevier B.V
- DOI
- 10.1046/j.1432-0436.2001.690201.x
- PMID
- 11798068
- ISSN
- 0301-4681
- eISSN
- 1432-0436
- Language
- English
- Date published
- 2001
- Academic Unit
- Stead Family Department of Pediatrics; Epidemiology; Biochemistry and Molecular Biology; Neonatology
- Record Identifier
- 9984024406302771
Metrics
16 Record Views