Journal article
Omega-3 fatty acid biomarkers and subsequent depressive symptoms
International journal of geriatric psychiatry, Vol.29(7), pp.747-757
07/2014
DOI: 10.1002/gps.4058
PMCID: PMC4048630
PMID: 24338726
Abstract
We sought to determine the relationship between the omega-3 fatty acid content of red blood cell membranes (RBC), in particular docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), and baseline and new-onset depressive symptoms in post-menopausal women. We secondarily sought to characterize the association between dietary omega-3 fatty acid intake and depressive symptomatology.
Study participants included 7086 members of the Women's Health Initiative Memory Study (aged 63-81 years) who had an assessment of RBC omega-3 fatty acid concentrations at the baseline screening visit. Depressive symptoms at baseline and follow-up were characterized using the Burnam eight-item scale for depressive disorders (Center for Epidemiologic Studies Depression Scale/Diagnostic Interview Schedule short form) and secondarily additionally inferred by antidepressant medication use.
In multivariable-adjusted models, our primary exposure, RBC DHA + EPA, was not related to depressive symptoms by any measure at baseline or follow-up, nor were RBC total omega-3, DHA, or EPA (all p > 0.2). In contrast, dietary intake of omega-3 was positively associated with depressive symptoms at baseline (adjusted odds ratio 1.082, 95% confidence interval 1.004-1.166; p = 0.04 for dietary DHA + EPA and Burnam score ≥0.06), although this generally did not persist at follow-up.
No relationship between RBC omega-3 levels and subsequent depressive symptoms was evident, and associations between dietary omega-3 and depressive symptoms were variable. Biomarkers of omega-3 status do not appear to be related to risk of new depression in post-menopausal women.
Details
- Title: Subtitle
- Omega-3 fatty acid biomarkers and subsequent depressive symptoms
- Creators
- Jane E Persons - Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, IA, USAJennifer G RobinsonEric M AmmannWilliam H CoryellMark A EspelandWilliam S HarrisJoAnn E MansonJess G Fiedorowicz
- Resource Type
- Journal article
- Publication Details
- International journal of geriatric psychiatry, Vol.29(7), pp.747-757
- Publisher
- England
- DOI
- 10.1002/gps.4058
- PMID
- 24338726
- PMCID
- PMC4048630
- ISSN
- 1099-1166
- eISSN
- 1099-1166
- Grant note
- HHSN268201100002I / NHLBI NIH HHS HHSN271201100004C / NIA NIH HHS HHSN268201100046C / PHS HHS HHSN268201100001C / WHI NIH HHS HHSN268201100004I / NHLBI NIH HHS HHSN271201100004C / PHS HHS 1K23MH083695-01A210 / NIMH NIH HHS K23 MH083695 / NIMH NIH HHS HHSN268201100003C / PHS HHS HHSN268201100004C / WHI NIH HHS HHSN268201100046C / NHLBI NIH HHS HHSN268201100002C / WHI NIH HHS HHSN268201100001I / NHLBI NIH HHS HHSN268201100004C / PHS HHS HHSN268201100002C / PHS HHS HHSN268201100003C / WHI NIH HHS HHSN268201100001C / PHS HHS
- Language
- English
- Date published
- 07/2014
- Academic Unit
- Psychiatry; Epidemiology; Iowa Neuroscience Institute; Internal Medicine
- Record Identifier
- 9983995044702771
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