Journal article
Omega-3 fatty acids and domain-specific cognitive aging: Secondary analyses of data from WHISCA
Neurology, Vol.81(17), pp.1484-1491
2013
DOI: 10.1212/WNL.0b013e3182a9584c
PMCID: PMC3888166
PMID: 24068783
Abstract
OBJECTIVE: To test the hypothesis that higher levels of red blood cell (RBC) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have a protective association with domain-specific cognitive function in women aged 65 years and older.METHODS: A total of 2,157 women with normal cognition enrolled in a clinical trial of postmenopausal hormone therapy were followed with annual cognitive testing for a median of 5.9 years. In this retrospective cohort study, we assessed the relationship between prerandomization RBC DHA + EPA levels and a) cognitive measures at baseline, and b) cognitive change over time. Endpoints were composite cognitive function and performance in 7 cognitive domains: fine motor speed, verbal memory, visual memory, spatial ability, verbal knowledge, verbal fluency, and working memory.RESULTS: After adjustment for demographic, clinical, and behavioral characteristics, no significant (p < 0.01) cross-sectional cognitive differences were found between women in the high and low DHA + EPA tertiles at the time of the first annual cognitive battery. In addition, no significant (p < 0.01) differences were found between the high and low DHA + EPA tertiles in the rate of cognitive change over time.CONCLUSIONS: We did not find an association between RBC DHA + EPA levels and age-associated cognitive decline in a cohort of older, dementia-free women.
Details
- Title: Subtitle
- Omega-3 fatty acids and domain-specific cognitive aging: Secondary analyses of data from WHISCA
- Creators
- Eric M AmmannJames V PottalaWilliam S HarrisMark A EspelandRobert WallaceNatalie L DenburgRyan M CarnahanJennifer G Robinson
- Resource Type
- Journal article
- Publication Details
- Neurology, Vol.81(17), pp.1484-1491
- DOI
- 10.1212/WNL.0b013e3182a9584c
- PMID
- 24068783
- PMCID
- PMC3888166
- NLM abbreviation
- Neurology
- ISSN
- 0028-3878
- eISSN
- 1526-632X
- Language
- English
- Date published
- 2013
- Academic Unit
- Neurology; Epidemiology; Psychological and Brain Sciences; Iowa Neuroscience Institute; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9983995166902771
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