Journal article
Omphalocele prevalence and co-occurring malformations: a nationwide register-based study of Danish live births in 1997–2021
Pediatric surgery international, Vol.41(1), 1
2025
DOI: 10.1007/s00383-024-05897-5
PMCID: PMC11584431
PMID: 39576336
Abstract
Purpose
Omphalocele is a congenital abdominal wall defect associated with a high risk of morbidity and mortality, with co-occurring congenital malformations often being the most important prognostic factor. High rates of spontaneous and medical terminations have been reported among pregnancies with omphalocele and co-occurring malformations. Few studies have focused on co-occurring malformations, particularly non-gastrointestinal malformations among live births. This study examined birth prevalence of omphalocele and co-occurring major malformations among a 25-year Danish liveborn cohort.
Methods
This nationwide retrospective prevalence study used data from the Danish National Patient Register and Danish Civil Registration System for infants who were delivered in Denmark during 1997–2021 and included in the Danish neonatal screening biobank. Diagnoses of omphalocele and co-occurring malformations were ascertained and prevalence estimated using Poisson regression.
Results
Among 1,498,685 live births, 147 infants with omphalocele were identified, yielding a combined and stable prevalence (per 10,000 infants) of 0.98 (95% CI 0.83–1.15). Over one-half (53.7%) presented with one or more major malformations, and an additional 17.0% were diagnosed with a syndrome.
Conclusions
Omphalocele birth prevalence in Denmark was stable over a recent 25-year period. The proportion of infants with co-occurring major malformations or diagnosed syndrome has important implications for long-term healthcare demands.
Details
- Title: Subtitle
- Omphalocele prevalence and co-occurring malformations: a nationwide register-based study of Danish live births in 1997–2021
- Creators
- Ulrik Lausten-Thomsen - RigshospitaletPaula L. Hedley - Statens Serum InstitutKristin M. Conway - University of Iowa, EpidemiologyKatrine M. Løfberg - RigshospitaletLars S. Johansen - RigshospitaletPaul A. Romitti - Statens Serum InstitutMichael Christiansen - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Pediatric surgery international, Vol.41(1), 1
- DOI
- 10.1007/s00383-024-05897-5
- PMID
- 39576336
- PMCID
- PMC11584431
- NLM abbreviation
- Pediatr Surg Int
- ISSN
- 0179-0358
- eISSN
- 1437-9813
- Publisher
- Springer Berlin Heidelberg
- Grant note
- U01 DD001307; U01 DD001307 / Centers for Disease Control and Prevention Foundation (http://dx.doi.org/10.13039/100020365)
- Language
- English
- Electronic publication date
- 11/22/2024
- Date published
- 2025
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9984749731302771
Metrics
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