On the mechanisms involved in antinociception induced by diphenyl diselenide

Fabricio B Zasso; Carlos E P Goncales; Eduardo A C Jung; Dioneia Araldi; Gilson Zeni; João B T Rocha; Cristina W Nogueira

doi:10.1016/j.etap.2004.08.003

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On the mechanisms involved in antinociception induced by diphenyl diselenide

Journal article

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On the mechanisms involved in antinociception induced by diphenyl diselenide

Fabricio B Zasso, Carlos E P Goncales, Eduardo A C Jung, Dioneia Araldi, Gilson Zeni, João B T Rocha and Cristina W Nogueira

Environmental toxicology and pharmacology, Vol.19(2), pp.283-289

02/01/2005

DOI: 10.1016/j.etap.2004.08.003

PMID: 21783487

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Abstract

In this study, we described the local peripheral antinociceptive activity produced by diphenyl diselenide in the formalin test as compared to ebselen, an amply studied organoselenium compound. A second objective was to evaluate, the possible mechanisms underlying the antinociceptive effect caused by diphenyl diselenide. Administration of diphenyl diselenide or ebselen produced a significant antinociceptive local effect on the late phase (15-30min) of the formalin test. As well, diphenyl diselenide and ebselen injected in the contra lateral paw produced a significant decrease in licking time on the late phase (15-30min). The mechanisms underlying the analgesic action of diphenyl diselenide seem to be unlike the activation of opioid, dopaminergic D2, muscarinic cholinergic receptors or the interaction with α(1) and α(2) adrenoceptors. Furthermore, the effect of a 5-HT(3) receptor antagonist in abolishing the antinociception induced by diphenyl diselenide suggests the involvement of serotonergic pathways.

Details

Title: Subtitle: On the mechanisms involved in antinociception induced by diphenyl diselenide
Creators: Fabricio B Zasso - Universidade Federal de Santa Maria
Carlos E P Goncales - Universidade Federal de Santa Maria
Eduardo A C Jung - Universidade Federal de Santa Maria
Dioneia Araldi - Universidade Federal de Santa Maria
Gilson Zeni - Universidade Federal de Santa Maria
João B T Rocha
Cristina W Nogueira - Universidade Federal de Santa Maria
Resource Type: Journal article
Publication Details: Environmental toxicology and pharmacology, Vol.19(2), pp.283-289
DOI: 10.1016/j.etap.2004.08.003
PMID: 21783487
NLM abbreviation: Environ Toxicol Pharmacol
ISSN: 1382-6689
eISSN: 1872-7077
Language: English
Date published: 02/01/2005
Academic Unit: Neuroscience and Pharmacology
Record Identifier: 9985177941202771

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