Journal article
On the radiobiological impact of metal artifacts in head-and-neck IMRT in terms of tumor control probability (TCP) and normal tissue complication probability (NTCP)
Medical & biological engineering & computing, Vol.45(11), pp.1045-1051
11/2007
DOI: 10.1007/s11517-007-0196-8
PMID: 17574487
Abstract
To investigate the effects of distorted head-and-neck (H&N) intensity-modulated radiation therapy (IMRT) dose distributions (hot and cold spots) on normal tissue complication probability (NTCP) and tumor control probability (TCP) due to dental-metal artifacts. Five patients’ IMRT treatment plans have been analyzed, employing five different planning image data-sets: (a) uncorrected (UC); (b) homogeneous uncorrected (HUC); (c) sinogram completion corrected (SCC); (d) minimum-value-corrected (MVC); and (e) streak-artifact-reduction including minimum-value-correction (SAR-MVC), which has been taken as the reference data-set. The effects on NTCP and TCP were evaluated using the Lyman-NTCP model and the Logistic-TCP model, respectively. When compared to the predicted NTCP obtained using the reference data-set, the treatment plan based on the original CT data-set (UC) yielded an increase in NTCP of 3.2 and 2.0% for the spared parotid gland and the spinal cord, respectively. While for the treatment plans based on the MVC CT data-set the NTCP increased by a 1.1% and a 0.1% for the spared parotid glands and the spinal cord, respectively. In addition, the MVC correction method showed a reduction in TCP for target volumes (MVC: ΔTCP = −0.6% vs. UC: ΔTCP = -1.9%) with respect to that of the reference CT data-set. Our results indicate that the presence of dental-metal-artifacts in H&N planning CT data-sets has an impact on the estimates of TCP and NTCP. In particular dental-metal-artifacts lead to an increase in NTCP for the spared parotid glands and a slight decrease in TCP for target volumes.
Details
- Title: Subtitle
- On the radiobiological impact of metal artifacts in head-and-neck IMRT in terms of tumor control probability (TCP) and normal tissue complication probability (NTCP)
- Creators
- Yusung Kim - Department of Medical Physics University of Wisconsin Madison USAWolfgang Tomé - Department of Human Oncology University of Wisconsin Medical School K4/344 CSC, 600 Highland Ave Madison WI 53792 USA
- Resource Type
- Journal article
- Publication Details
- Medical & biological engineering & computing, Vol.45(11), pp.1045-1051
- Publisher
- Springer-Verlag; Berlin/Heidelberg
- DOI
- 10.1007/s11517-007-0196-8
- PMID
- 17574487
- ISSN
- 0140-0118
- eISSN
- 1741-0444
- Language
- English
- Date published
- 11/2007
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984047628002771
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