On the role of modeling choices in estimation of cerebral aneurysm wall tension

Manasi Ramachandran; Aki Laakso; Robert E Harbaugh; Madhavan L Raghavan

doi:10.1016/j.jbiomech.2012.07.029

Back

On the role of modeling choices in estimation of cerebral aneurysm wall tension

Journal article

Peer reviewed

On the role of modeling choices in estimation of cerebral aneurysm wall tension

Manasi Ramachandran, Aki Laakso, Robert E Harbaugh and Madhavan L Raghavan

Journal of biomechanics, Vol.45(16), pp.2914-2919

11/15/2012

DOI: 10.1016/j.jbiomech.2012.07.029

PMCID: PMC3593074

PMID: 23021608

View Online

Abstract

To assess various approaches to estimating pressure-induced wall tension in intracranial aneurysms (IA) and their effect on the stratification of subjects in a study population. Three-dimensional models of 26 IAs (9 ruptured and 17 unruptured) were segmented from Computed Tomography Angiography (CTA) images. Wall tension distributions in these patient-specific geometric models were estimated based on various approaches such as differences in morphological detail utilized or modeling choices made. For all subjects in the study population, the peak wall tension was estimated using all investigated approaches and were compared to a reference approach—nonlinear finite element (FE) analysis using the Fung anisotropic model with regionally varying material fiber directions. Comparisons between approaches were focused toward assessing the similarity in stratification of IAs within the population based on peak wall tension. The stratification of IAs tension deviated to some extent from the reference approach as less geometric detail was incorporated. Interestingly, the size of the cerebral aneurysm as captured by a single size measure was the predominant determinant of peak wall tension-based stratification. Within FE approaches, simplifications to isotropy, material linearity and geometric linearity caused a gradual deviation from the reference estimates, but it was minimal and resulted in little to no impact on stratifications of IAs. Differences in modeling choices made without patient-specificity in parameters of such models had little impact on tension-based IA stratification in this population. Increasing morphological detail did impact the estimated peak wall tension, but size was the predominant determinant.

Biomechanics

Finite element method

Wall tension

Intracranial aneurysm

Material models

Details

Title: Subtitle: On the role of modeling choices in estimation of cerebral aneurysm wall tension
Creators: Manasi Ramachandran - Department of Biomedical Engineering, University of Iowa, Iowa City, IA, USA
Aki Laakso - Department of Neurosurgery, Helsinki University Central Hospital, Helsinki, Finland
Robert E Harbaugh - Department of Neurosurgery, Penn State Milton S. Hershey Medical Center, Penn State University, Hershey, PA, USA
Madhavan L Raghavan - Department of Biomedical Engineering, University of Iowa, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Journal of biomechanics, Vol.45(16), pp.2914-2919
DOI: 10.1016/j.jbiomech.2012.07.029
PMID: 23021608
PMCID: PMC3593074
NLM abbreviation: J Biomech
ISSN: 0021-9290
eISSN: 1873-2380
Publisher: Elsevier Ltd
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health, award: 3R01HL083475
Language: English
Date published: 11/15/2012
Academic Unit: Roy J. Carver Department of Biomedical Engineering
Record Identifier: 9984064256602771

Metrics

20 Record Views

14 Times Cited - Web of Science