Journal article
Once-Daily, High-Dose Levofloxacin versus Ticarcillin-Clavulanate Alone or Followed by Amoxicillin-Clavulanate for Complicated Skin and Skin-Structure Infections: A Randomized, Open-Label Trial
Clinical infectious diseases, Vol.35(4), pp.381-389
08/15/2002
DOI: 10.1086/341026
PMID: 12145720
Abstract
This study tested whether levofloxacin, at a new high dose of 750 mg, was effective for the treatment of complicated skin and skin-structure infections (SSSIs). Patients with complicated SSSIs (n = 399) were randomly assigned in a ratio of 1 : 1 to 2 treatment arms: levofloxacin (750 mg given once per day intravenously [iv], orally, or iv/orally) or ticarcillin-clavulanate (TC; 3.1 g given iv every 4–6 hours) followed, at the investigator's discretion, by amoxicillin-clavulanate (AC; 875 mg given orally every 12 hours). In the clinically evaluable population, therapeutic equivalence was demonstrated between the levofloxacin and TC/AC regimens (success rates of 84.1% and 80.3%, respectively). In the microbiologically evaluable population, the overall rate of eradication was 83.7% in the levofloxacin treatment group and 71.4% in the TC/AC treatment group (95% confidence interval, -24.3 to -0.2). Both levofloxacin and TC/AC were well tolerated. These data demonstrate that levofloxacin (750 mg once per day) is safe and at least as effective as TC/AC for complicated SSSIs
Details
- Title: Subtitle
- Once-Daily, High-Dose Levofloxacin versus Ticarcillin-Clavulanate Alone or Followed by Amoxicillin-Clavulanate for Complicated Skin and Skin-Structure Infections: A Randomized, Open-Label Trial
- Creators
- Donald R Graham - Springfield ClinicDavid A Talan - University of California, Los AngelesRonald L Nichols - Tulane Medical CenterChristopher Lucasti - South Jersey Infectious Disease, Somers PointMichael Corrado - Advanced Biologics, LambertvilleNancy Morgan - Johnson & Johnson Pharmaceutical Research and DevelopmentCynthia L Fowler - Johnson & Johnson Pharmaceutical Research and Development
- Resource Type
- Journal article
- Publication Details
- Clinical infectious diseases, Vol.35(4), pp.381-389
- Publisher
- The University of Chicago Press
- DOI
- 10.1086/341026
- PMID
- 12145720
- ISSN
- 1058-4838
- eISSN
- 1537-6591
- Language
- English
- Date published
- 08/15/2002
- Academic Unit
- Emergency Medicine; Internal Medicine
- Record Identifier
- 9984297152402771
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