Journal article
One MAC of sevoflurane provides protection against reperfusion injury in the rat heart in vivo
British journal of anaesthesia : BJA, Vol.87(6), pp.905-911
12/01/2001
DOI: 10.1093/bja/87.6.905
PMID: 11878695
Abstract
Volatile anaesthetics protect the heart against reperfusion injury. We investigated whether the cardioprotection induced by sevoflurane against myocardial reperfusion injury was concentration-dependent. Fifty-eight α-chloralose anaesthetized rats were subjected to 25 min of coronary artery occlusion followed by 90 min of reperfusion. Sevoflurane was administered for the first 15 min of reperfusion at concentrations corresponding to 0.75 (n=11), 1.0 (n=11), 1.5 (n=13), or 2.0 MAC (n=12). Eleven rats served as untreated controls. Left ventricular peak systolic pressure (LVPSP, tipmanometer) and cardiac output (CO, flowprobe) was measured. Infarct size (IS, triphenyltetrazolium staining) was determined as percentage of the area at risk. Baseline LVPSP was 131 (126–135) mm Hg (mean (95% confidence interval)) and CO 33 (31–36) ml min−1, similar in all groups. During early reperfusion, sevoflurane reduced LVPSP in a concentration-dependent manner to 78 (67–89)% of baseline at 0.75 MAC (not significant vs controls 99 (86–112)%), 71 (62–80)% at 1 MAC (P<0.05), 66 (49–83)% at 1.5 MAC (P<0.05) and 56 (47–65)% at 2 MAC (P<0.05). CO remained constant. While 0.75 MAC of sevoflurane had no effect on IS (34 (27–41)% of the area at risk) compared with controls (38 (31–45)%, P=0.83), 1.0 MAC reduced IS markedly to 23 (17–30)% (P<0.05). Increasing the concentration to 1.5 MAC (23 (17–30)%) and 2 MAC (23 (13–32)%, both P<0.05 vs controls) had no additional protective effect. One MAC sevoflurane protected against myocardial reperfusion injury. Increasing the sevoflurane concentration above 1 MAC resulted in no further protection.
Details
- Title: Subtitle
- One MAC of sevoflurane provides protection against reperfusion injury in the rat heart in vivo
- Creators
- D. Obal - Heinrich Heine University DüsseldorfB. Preckel - Heinrich Heine University DüsseldorfH. Scharbatke - Heinrich Heine University DüsseldorfJ. Müllenheim - Heinrich Heine University DüsseldorfF. Höterkes - Heinrich Heine University DüsseldorfV. Thämer - Heinrich Heine University DüsseldorfW. Schlack - Heinrich Heine University Düsseldorf
- Resource Type
- Journal article
- Publication Details
- British journal of anaesthesia : BJA, Vol.87(6), pp.905-911
- DOI
- 10.1093/bja/87.6.905
- PMID
- 11878695
- NLM abbreviation
- Br J Anaesth
- ISSN
- 0007-0912
- eISSN
- 1471-6771
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 12/01/2001
- Academic Unit
- Anesthesia
- Record Identifier
- 9984696579802771
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