Ontogenetic change in the auditory conditioned stimulus pathway for eyeblink conditioning

John H Freeman; Matthew M Campolattaro

doi:10.1101/lm.1131208

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Ontogenetic change in the auditory conditioned stimulus pathway for eyeblink conditioning

Journal article

Open access

Peer reviewed

Ontogenetic change in the auditory conditioned stimulus pathway for eyeblink conditioning

John H Freeman and Matthew M Campolattaro

Learning & memory (Cold Spring Harbor, N.Y.), Vol.15(11), pp.823-828

11/2008

DOI: 10.1101/lm.1131208

PMCID: PMC2632811

PMID: 18984563

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https://doi.org/10.1101/lm.1131208View

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Abstract

Two experiments examined the neural mechanisms underlying the ontogenetic emergence of auditory eyeblink conditioning. Previous studies found that the medial auditory thalamus is necessary for eyeblink conditioning with an auditory conditioned stimulus (CS) in adult rats. In experiment 1, stimulation of the medial auditory thalamus was used as a CS in rat pups trained on postnatal days (P) 17-18, 24-25, or 31-32. All three age groups showed significant acquisition relative to unpaired controls. However, there was an age-related increase in the rate of conditioning. Experiment 2 examined the effect of inactivating the medial auditory thalamus with muscimol on auditory eyeblink conditioning in rats trained on P17-18, 24-25, or 31-32. Rat pups trained on P24-25 and P31-32, but not P17-18, showed a significant reduction in conditioned responses following muscimol infusions. The findings suggest that the thalamic contribution to auditory eyeblink conditioning continues to develop through the first postnatal month.

Animals, Newborn

Muscimol - pharmacology

Age Factors

Blinking - drug effects

Rats

Reaction Time - physiology

Thalamus - drug effects

Auditory Pathways - growth & development

Blinking - physiology

Conditioning, Eyelid - physiology

Animals

Aging - physiology

Analysis of Variance

Auditory Pathways - physiology

Thalamus - physiology

Acoustic Stimulation - adverse effects

GABA Agonists - pharmacology

Conditioning, Eyelid - drug effects

Details

Title: Subtitle: Ontogenetic change in the auditory conditioned stimulus pathway for eyeblink conditioning
Creators: John H Freeman - Department of Psychology, University of Iowa, Iowa City, Iowa 52242, USA. john-freeman@uiowa.edu
Matthew M Campolattaro
Resource Type: Journal article
Publication Details: Learning & memory (Cold Spring Harbor, N.Y.), Vol.15(11), pp.823-828
Publisher: United States
DOI: 10.1101/lm.1131208
PMID: 18984563
PMCID: PMC2632811
ISSN: 1072-0502
eISSN: 1549-5485
Grant note: NS038890 / NINDS NIH HHS R01 NS038890 / NINDS NIH HHS
Language: English
Date published: 11/2008
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984065753202771

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