Journal article
Ontogeny of baroreflex control of renal sympathetic nerve activity and heart rate
American journal of physiology. Heart and circulatory physiology, Vol.263(6), pp.H1819-H1826
12/01/1992
DOI: 10.1152/ajpheart.1992.263.6.H1819
PMID: 1481906
Abstract
The purpose of this study was to characterize the developmental changes in baroreflex function during fetal and postnatal life in sheep. Resting mean arterial blood pressure increased significantly from 55 +/- 2 mmHg in fetuses to 86 +/- 3 mmHg in newborn lambs and to 105 +/- 4 mmHg in 4- to 6-wk-old lambs. The sensitivity (gain) of the renal sympathetic nerve activity (RSNA) response to baroreceptor stimulation was greater (P < 0.05) in fetuses (-7.7 +/- 1.9%/mmHg) than in newborn (-2.9 +/- 0.1%/mmHg) and 4- to 6-wk-old lambs (-2.2 +/- 0.2%/mmHg). The threshold and saturation pressures for the baroreflex function curve were lower (P < 0.05) in fetuses (44 +/- 2 and 61 +/- 2 mmHg) than in newborn (59 +/- 4 and 106 +/- 5 mmHg) or 4- to 6-wk-old lambs (78 +/- 5 and 132 +/- 6 mmHg). Similar findings were observed when the heart rate response to baroreceptor stimulation was examined. Additional experiments were performed in newborn and 4- to 6-wk-old lambs to determine whether the rise in arterial blood pressure associated with postnatal maturation contributed to baroreflex resetting. Sustained elevation of arterial blood pressure by 15–20 mmHg for over 90 min did not reset the baroreflex function curve in either newborn or 4- to 6-wk-old lambs.
Details
- Title: Subtitle
- Ontogeny of baroreflex control of renal sympathetic nerve activity and heart rate
- Creators
- Jeffrey L Segar - University of IowaGeorge Hajduczok - University of IowaBruce A Smith - University of IowaDavid C Merrill - University of Iowa Hospitals and ClinicsJean E Robillard - University of Iowa
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Heart and circulatory physiology, Vol.263(6), pp.H1819-H1826
- DOI
- 10.1152/ajpheart.1992.263.6.H1819
- PMID
- 1481906
- ISSN
- 0363-6135
- eISSN
- 1522-1539
- Language
- English
- Date published
- 12/01/1992
- Academic Unit
- Molecular Physiology and Biophysics; Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Medicine Administration
- Record Identifier
- 9984774211602771
Metrics
5 Record Views