Journal article
Ontogeny of neuronally released norepinephrine on renin secretion in sheep
The American journal of physiology, Vol.257(4 Pt 2), pp.R765-R770
10/1989
DOI: 10.1152/ajpregu.1989.257.4.R765
PMID: 2679151
Abstract
The role of renal nerves and norepinephrine release on renin secretion during fetal and postnatal maturation has not been studied. Experiments were performed to determine the effect of veratridine, a substance known to promote norepinephrine release from nerve terminals, on active and inactive renin secretion from renal cortical slices of fetal (134-138 days gestation; term is 145 days), newborn (4-9 days of age), and adult nonpregnant sheep. Veratridine (10-300 microM) significantly increased active renin secretion and produced a small but nonsignificant rise in inactive renin secretion in all three groups of animals (P less than 0.05). The percent rise in active renin secretion during veratridine stimulation was similar among all groups. Veratridine-stimulated (300 microM) active renin secretion was antagonized by tetrodotoxin (0.5 and 5.0 microM) and DL-propranolol (1 microM) in fetal renal cortical slices. However, neither tetrodotoxin nor propranolol completely inhibited the stimulatory effect of veratridine on active renin secretion. These results suggest that 1) norepinephrine released from nerve terminals may regulate active renin secretion early during development; 2) the effect of veratridine on active renin secretion was similar in fetal, newborn, and adult sheep; 3) veratridine had no significant effect on inactive renin secretion; and 4) active renin secretion due to depolarization of nerve terminals in fetal sheep is dependent on activation of beta-adrenoceptors as it is in adults.
Details
- Title: Subtitle
- Ontogeny of neuronally released norepinephrine on renin secretion in sheep
- Creators
- Kenneth T Nakamura - University of IowaJon M Klinkefus - University of IowaFrancine G Smith - University of IowaTadashi Sato - University of IowaJean E Robillard - University of Iowa
- Resource Type
- Journal article
- Publication Details
- The American journal of physiology, Vol.257(4 Pt 2), pp.R765-R770
- DOI
- 10.1152/ajpregu.1989.257.4.R765
- PMID
- 2679151
- ISSN
- 0002-9513
- eISSN
- 1522-1490
- Grant note
- HD-20576 / NICHD NIH HHS HL-35600 / NHLBI NIH HHS DK-38302 / NIDDK NIH HHS
- Language
- English
- Date published
- 10/1989
- Academic Unit
- Molecular Physiology and Biophysics; Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Medicine Administration
- Record Identifier
- 9984773398802771
Metrics
2 Record Views