Journal article
Ontogeny of renal hemodynamic response to terbutaline and forskolin in sheep
The Journal of pharmacology and experimental therapeutics, Vol.247(2), pp.453-459
11/01/1988
DOI: 10.1016/S0022-3565(25)13385-5
PMID: 3183947
Abstract
The renal hemodynamic response to renal arterial infusions of terbutaline and forskolin were compared in chronically instrumented fetal (129-139 days gestation; term 145 days), newborn (7-14 days old) and nonpregnant adult sheep. Infusions of terbutaline produced renal vasodilation in all age groups with maximal increases being higher in fetal (47 +/- 7%) than in newborn (30 +/- 8%) or adult sheep (24 +/- 5%). Terbutaline-mediated renal vasodilation was inhibited by the selective beta 2 adrenoceptor antagonist, ICI 118,551, whereas infusion of selective beta 1 adrenoceptor antagonist, ICI 89,406, had no effect. Moreover, terbutaline effects were unchanged after phentolamine infusion to inhibit potential antagonistic effects of neuronal norepinephrine release by presynaptic beta 2 adrenoceptor stimulation. Renal arterial infusion of forskolin produced renal vasodilation of similar magnitude in all age groups, with maximal increases of 46 +/- 5, 38 +/- 3 and 38 +/- 5% in fetal, newborn and adult sheep, respectively. Taken together, these results suggest that renal vasodilatory mechanisms stimulated by selective activation of beta 2 adrenoceptors (terbutaline) are greater during fetal life. However, direct activation of adenylate cyclase with forskolin produces essentially similar renal vasodilatory responses during development in sheep. Thus, reasons to explain age-dependent differences in renal vasodilation observed previously with endogenous catecholamines may be at the receptor-hormone level.
Details
- Title: Subtitle
- Ontogeny of renal hemodynamic response to terbutaline and forskolin in sheep
- Creators
- Kenneth T Nakamura - University of IowaBeth M Alden - University of IowaG Paul Matherne - Univ. Iowa coll. medicine, dep. pediatrics, Iowa City IA, United StatesPedro A Jose - Univ. Iowa coll. medicine, dep. pediatrics, Iowa City IA, United StatesJean E Robillard - University of Iowa
- Resource Type
- Journal article
- Publication Details
- The Journal of pharmacology and experimental therapeutics, Vol.247(2), pp.453-459
- Publisher
- American Society for Pharmacology and Experimental Therapeutics
- DOI
- 10.1016/S0022-3565(25)13385-5
- PMID
- 3183947
- ISSN
- 0022-3565
- eISSN
- 1521-0103
- Number of pages
- 7
- Language
- English
- Date published
- 11/01/1988
- Academic Unit
- Molecular Physiology and Biophysics; Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Medicine Administration
- Record Identifier
- 9984773402702771
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