Ontogeny of renal β-adrenoceptor-mediated vasodilation in sheep: comparison between endogenous catecholamines

K. T NAKAMURA; G. P MATHERNE; P. A JOSE; B. M ALDEN; J. E ROBILLARD

doi:10.1203/00006450-198710000-00022

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Ontogeny of renal β-adrenoceptor-mediated vasodilation in sheep: comparison between endogenous catecholamines

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Ontogeny of renal β-adrenoceptor-mediated vasodilation in sheep: comparison between endogenous catecholamines

K. T NAKAMURA, G. P MATHERNE, P. A JOSE, B. M ALDEN and J. E ROBILLARD

Pediatric research, Vol.22(4), pp.465-470

1987

DOI: 10.1203/00006450-198710000-00022

PMID: 2825107

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Abstract

The renal hemodynamic response to renal arterial infusions of norepinephrine was compared to epinephrine infusions during renal a-adrenoceptor blockade in chronically instrumented and unanesthetized fetal (127- 141 days gestation; term 145 days), newborn (6-10 days old), and nonpregnant adult sheep. Infusions of either catecholamines produced renal vasodilation which was of greater magnitude in fetal compared to newborn and adult sheep. Maximal increases in renal blood flow velocity during norepinephrine infusion were 64 ± 5% in fetal, 23 ± 4% in newborn, and 24 ± 7% in adult sheep (p < 0.001). Similar age-dependent increases in renal blood flow velocity were observed during epinephrine infusion, with maximal changes being 74 ± 10% in fetal, 23 ± 4% in newborn, and 19 ± 4% in adult sheep (p < 0.001). Increases in renal blood flow velocity produced by both norepinephrine and epinephrine infusions were completely inhibited by intrarenal infusion of ICI118,551, a fo-adrenoceptor antagonist. Taken together, these results suggest that the renal vascular fo-adrenergic receptor that mediates vasodilation may be stimulated by both norepinephrine and epinephrine with equal potency. In addition, results of this study demonstrate that enhanced/32-adrenoceptor mediated renal vasodilatory capacity is observed during fetal life.

Fundamental and applied biological sciences. Psychology

Biological and medical sciences

Organogenesis. Physiological fonctions

Organogenesis. Fetal development

Embryology: invertebrates and vertebrates. Teratology

Details

Title: Subtitle: Ontogeny of renal β-adrenoceptor-mediated vasodilation in sheep: comparison between endogenous catecholamines
Creators: K. T NAKAMURA - Univ. Iowa coll. medicine, dep. pediatrics, Iowa City IA 52242, United States
G. P MATHERNE - Univ. Iowa coll. medicine, dep. pediatrics, Iowa City IA 52242, United States
P. A JOSE - Univ. Iowa coll. medicine, dep. pediatrics, Iowa City IA 52242, United States
B. M ALDEN - Univ. Iowa coll. medicine, dep. pediatrics, Iowa City IA 52242, United States
J. E ROBILLARD - Univ. Iowa coll. medicine, dep. pediatrics, Iowa City IA 52242, United States
Resource Type: Journal article
Publication Details: Pediatric research, Vol.22(4), pp.465-470
DOI: 10.1203/00006450-198710000-00022
PMID: 2825107
NLM abbreviation: Pediatr Res
ISSN: 0031-3998
eISSN: 1530-0447
Publisher: Lippincott Williams & Wilkins; Hagerstown, MD
Language: English
Date published: 1987
Academic Unit: Molecular Physiology and Biophysics; Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Medicine Administration
Record Identifier: 9984025464202771

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