Journal article
Operational challenges in the COVID‐19 era: Asymptomatic infections and vaccination timing
Clinical transplantation, Vol.35(11), pp.e14437-n/a
11/2021
DOI: 10.1111/ctr.14437
PMCID: PMC8420523
PMID: 34297878
Abstract
The coronavirus disease 2019 (COVID-19) pandemic has created unprecedented challenges for solid organ transplant programs. While transplant activity has largely recovered, appropriate management of deceased donor candidates who are asymptomatic but have positive nucleic acid testing (NAT) for SARS-CoV-2 is unclear, as this result may reflect active infection or prolonged viral shedding. Furthermore, candidates who are unvaccinated or partially vaccinated continue to receive donor offers. In the absence of robust outcomes data, transplant professionals at US adult kidney transplant centers were surveyed (February 13, 2021 to April 29, 2021) to determine community practice (N: 92 centers, capturing 41% of centers and 57% of transplants performed). The majority (97%) of responding centers declined organs for asymptomatic NAT+ patients without documented prior infection. However, 32% of centers proceed with kidney transplant in NAT+ patients who were at least 30 days from initial diagnosis with negative chest imaging. Less than 7% of programs reported inactivating patients who were unvaccinated or partially vaccinated. In conclusion, despite national recommendations to wait for negative testing, many centers are proceeding with kidney transplant in patients with positive SARS-CoV-2 NAT results due to presumed viral shedding. Furthermore, few centers are requiring COVID-19 vaccination prior to transplantation at this time.
Details
- Title: Subtitle
- Operational challenges in the COVID‐19 era: Asymptomatic infections and vaccination timing
- Creators
- David A. Axelrod - University of IowaDilek Ince - University of IowaMeera N. Harhay - Drexel UniversityRoslyn B. Mannon - University of Nebraska at OmahaTarek Alhamad - Washington University in St. LouisMatthew Cooper - Medstar Georgetown Transplant Institute, Washington DC USA.Michelle A. Josephson - University of ChicagoYasar Caliskan - Saint Louis UniversityAsif Sharfuddin - Indiana University – Purdue University IndianapolisVineeta Kumar - University of Alabama at BirminghamAlexis Guenette - Saint Louis UniversityMark A. Schnitzler - Saint Louis UniversitySruthi Ainapurapu - Saint Louis UniversityKrista L. Lentine - Saint Louis University Center for Abdominal Transplantation St. Louis Missouri USA
- Resource Type
- Journal article
- Publication Details
- Clinical transplantation, Vol.35(11), pp.e14437-n/a
- DOI
- 10.1111/ctr.14437
- PMID
- 34297878
- PMCID
- PMC8420523
- ISSN
- 0902-0063
- eISSN
- 1399-0012
- Language
- English
- Date published
- 11/2021
- Academic Unit
- Infectious Diseases; Surgery; Internal Medicine
- Record Identifier
- 9984322952402771
Metrics
22 Record Views