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Operationalizing compensation over time in neurodegenerative disease
Journal article   Open access   Peer reviewed

Operationalizing compensation over time in neurodegenerative disease

Sarah Gregory, Jeffrey D Long, Stefan Klöppel, Adeel Razi, Elisa Scheller, Lora Minkova, Marina Papoutsi, James A Mills, Alexandra Durr, Blair R Leavitt, …
Brain (London, England : 1878), Vol.140(4), pp.1158-1165
04/2017
DOI: 10.1093/brain/awx022
PMCID: PMC5382953
PMID: 28334888
url
https://doi.org/10.1093/brain/awx022View
Published (Version of record) Open Access

Abstract

In pre-clinical Huntington's disease, normal behaviour is maintained despite neurodegeneration, suggesting a mechanism of compensation. Gregory, Long et al . present two mathematical models of compensation over time and their operationalisation for neuroimaging.
neurodegeneration longitudinal analysis Dorsal column compensation Huntington’s disease MRI

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