Ophthalmologic complications in children with chronic hepatitis C treated with pegylated interferon

Michael R Narkewicz; Philip Rosenthal; Kathleen B Schwarz; Arlene Drack; Todd Margolis; Michael X Repka; PEDS-C Study Group

doi:10.1097/MPG.0b013e3181b99cf0

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Ophthalmologic complications in children with chronic hepatitis C treated with pegylated interferon

Journal article

Open access

Peer reviewed

Ophthalmologic complications in children with chronic hepatitis C treated with pegylated interferon

Michael R Narkewicz, Philip Rosenthal, Kathleen B Schwarz, Arlene Drack, Todd Margolis, Michael X Repka and PEDS-C Study Group

Journal of pediatric gastroenterology and nutrition, Vol.51(2), pp.183-186

08/2010

DOI: 10.1097/MPG.0b013e3181b99cf0

PMCID: PMC2910798

PMID: 20512062

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Abstract

Interferon treatment for chronic viral hepatitis C (HCV) has been associated with the development of retinopathy in 19% to 29% of adults. Our purpose is to describe the ophthalmologic complications of pegylated interferon-alpha2a with either placebo or ribavirin in children with chronic HCV (the PEDS-C trial). Prospective, comprehensive ophthalmologic examinations including slit lamp at enrollment and after 24 and 48 weeks of treatment of 114 children participating in a randomized clinical trial. One hundred and twenty-eight children were screened for entry, of whom 123 had an eye examination and no child had existing retinal disease. One hundred fourteen children were eligible and were treated. One hundred ten children had an eye examination at 24 weeks and 103 children at 48 weeks. Three of 114 subjects (2.6%) developed documented (n = 2) or possible (1) serious eye complications. One subject developed evidence of ischemic retinopathy (cotton-wool spots) by week 24, 1 developed uveitis by week 48, and 1 reported at week 48 transient (<4 hours) monocular blindness that had occurred at week 36 with a subsequent normal examination at week 48. Ophthalmologic complications are infrequent in children who are treated with pegylated interferon-alpha2a for HCV (2%-3%). Because of the potential severity of ischemic retinopathy and uveitis, prospective ocular assessment should remain part of the monitoring strategy for children who are treated with interferon for HCV.

Antiviral Agents - therapeutic use

Humans

Retinal Diseases - chemically induced

Interferon-alpha - therapeutic use

Child, Preschool

Hepatitis C, Chronic - virology

Male

Recombinant Proteins

Hepatitis C, Chronic - drug therapy

Antiviral Agents - adverse effects

Adolescent

Female

Interferon-alpha - adverse effects

Ischemia - chemically induced

Child

Uveitis - chemically induced

Blindness - chemically induced

Details

Title: Subtitle: Ophthalmologic complications in children with chronic hepatitis C treated with pegylated interferon
Creators: Michael R Narkewicz - Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, University of Colorado Denver School of Medicine and the Children's Hospital, Aurora, CO 80045, USA. narkewicz.michael@tchden.org
Philip Rosenthal
Kathleen B Schwarz
Arlene Drack
Todd Margolis
Michael X Repka
PEDS-C Study Group
Resource Type: Journal article
Publication Details: Journal of pediatric gastroenterology and nutrition, Vol.51(2), pp.183-186
DOI: 10.1097/MPG.0b013e3181b99cf0
PMID: 20512062
PMCID: PMC2910798
NLM abbreviation: J Pediatr Gastroenterol Nutr
ISSN: 0277-2116
eISSN: 1536-4801
Publisher: United States
Grant note: UL1 RR 025005 / NCRR NIH HHS U01 DK067767-02 / NIDDK NIH HHS U01 DK067767-04 / NIDDK NIH HHS U01DK067767-01 / NIDDK NIH HHS M01 RR00069 / NCRR NIH HHS UL1 RR025005 / NCRR NIH HHS U01 DK067767-05 / NIDDK NIH HHS U01 DK067767 / NIDDK NIH HHS U01 DK067767-03 / NIDDK NIH HHS M01 RR000069 / NCRR NIH HHS U01 DK067767-05S1 / NIDDK NIH HHS U01 DK067767-01 / NIDDK NIH HHS
Language: English
Date published: 08/2010
Academic Unit: Stead Family Department of Pediatrics; Ophthalmology and Visual Sciences
Record Identifier: 9983980389602771

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