Journal article
Opioid Receptor Blockade Prevents Propofol-induced Hypotension in Rats
Journal of neurosurgical anesthesiology, Vol.24(3), pp.191-196
07/01/2012
DOI: 10.1097/ANA.0b013e318248ad01
PMID: 22314307
Abstract
Background: Propofol is an intravenous anesthetic that is widely used to anesthetize patients during neurosurgical procedures. Although propofol is considered to be an essential component of contemporary management of acute brain injury in the operating room and in critical care settings, propofol-induced hypotension (PIH) remains a frequent and undesirable side effect. After 3 decades of clinical use, multiple proposed causes of PIH, and conflicting experimental results, the mechanism of PIH is still a puzzle for neuroscience and anesthesiology. This study evaluated the role of opioid receptors in PIH.
Methods: Pentobarbital-anesthetized rats were subjected to systemic or central pretreatment with naloxone followed by intravenous or central administration of propofol.
Results: In the absence of pretreatment with naloxone, intravenous (7.5 mg/kg) and intracistenal propofol (10 mu g) injection induced 45% and 35% reductions in the mean arterial pressure, respectively (P < 0.05). Both systemic (5 mg/kg) and central (100 mg) pretreatment with naloxone prevented PIH without independently affecting mean arterial pressure.
Conclusions: This experiment in anesthetized rats indicates that central and peripheral opioid receptor blockade prevents PIH, suggesting that these receptors are involved in the cardiovascular alterations elicited by propofol administration.
Details
- Title: Subtitle
- Opioid Receptor Blockade Prevents Propofol-induced Hypotension in Rats
- Creators
- Luiz F. Maracaja-Neto - Suny Downstate Med Ctr, Dept Anesthesiol, Brooklyn, NY USAGeraldo A. Mello Silva - Univ Estado Rio De Janeiro, Dept Pharmacol & Neurobiol, Rio De Janeiro, BrazilRoberto Soares de Moura - Universidade do Estado do Rio de JaneiroEduardo Tibirica - Fundação Oswaldo CruzMarcos A. Lessa - University of Iowa, Anesthesia
- Resource Type
- Journal article
- Publication Details
- Journal of neurosurgical anesthesiology, Vol.24(3), pp.191-196
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1097/ANA.0b013e318248ad01
- PMID
- 22314307
- ISSN
- 0898-4921
- eISSN
- 1537-1921
- Number of pages
- 6
- Grant note
- FAPERJ; Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio De Janeiro (FAPERJ) Fiocruz CNPq; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ)
- Language
- English
- Date published
- 07/01/2012
- Academic Unit
- Anesthesia
- Record Identifier
- 9984656537702771
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