Opioidergic signaling contributes to food-mediated suppression of AgRP neurons

Nilufer Sayar-Atasoy; Yavuz Yavuz; Connor Laule; Chunyang Dong; Hyojin Kim; Jacob Rysted; Kyle Flippo; Debbie Davis; Iltan Aklan; Bayram Yilmaz; Lin Tian; Deniz Atasoy

doi:10.1016/j.celrep.2023.113630

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Opioidergic signaling contributes to food-mediated suppression of AgRP neurons

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Opioidergic signaling contributes to food-mediated suppression of AgRP neurons

Nilufer Sayar-Atasoy, Yavuz Yavuz, Connor Laule, Chunyang Dong, Hyojin Kim, Jacob Rysted, Kyle Flippo, Debbie Davis, Iltan Aklan, Bayram Yilmaz, …

Cell reports (Cambridge), Vol.43(1), 113630

01/01/2024

DOI: 10.1016/j.celrep.2023.113630

PMCID: PMC10865729

PMID: 38165803

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Abstract

Opioids are generally known to promote hedonic food consumption. Although much of the existing evidence is primarily based on studies of the mesolimbic pathway, endogenous opioids and their receptors are widely expressed in hypothalamic appetite circuits as well; however, their role in homeostatic feeding remains unclear. Using a fluorescent opioid sensor, deltaLight, here we report that mediobasal hypothalamic opioid levels increase by feeding, which directly and indirectly inhibits agouti-related protein (AgRP)-expressing neurons through the μ-opioid receptor (MOR). AgRP-specific MOR expression increases by energy surfeit and contributes to opioid-induced suppression of appetite. Conversely, its antagonists diminish suppression of AgRP neuron activity by food and satiety hormones. Mice with AgRP neuron-specific ablation of MOR expression have increased fat preference without increased motivation. These results suggest that post-ingestion release of endogenous opioids contributes to AgRP neuron inhibition to shape food choice through MOR signaling.

MOR

satiety

CP: Metabolism

CP: Neuroscience

feeding

opioid

diet-preference

AgRP

endorphin

Details

Title: Subtitle: Opioidergic signaling contributes to food-mediated suppression of AgRP neurons
Creators: Nilufer Sayar-Atasoy - Department of Neuroscience and Pharmacology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Yavuz Yavuz - Yeditepe University
Connor Laule - University of Iowa
Chunyang Dong - University of California, Davis
Hyojin Kim - University of Iowa
Jacob Rysted - University of Iowa
Kyle Flippo - University of Iowa
Debbie Davis - Department of Neuroscience and Pharmacology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Iltan Aklan - University of Iowa
Bayram Yilmaz - Yeditepe University
Lin Tian - University of California, Davis
Deniz Atasoy - University of Iowa
Resource Type: Journal article
Publication Details: Cell reports (Cambridge), Vol.43(1), 113630
DOI: 10.1016/j.celrep.2023.113630
PMID: 38165803
PMCID: PMC10865729
NLM abbreviation: Cell Rep
ISSN: 2211-1247
eISSN: 2211-1247
Grant note: R01 DK126740 / NIDDK NIH HHS
Language: English
Date published: 01/01/2024
Academic Unit: Neurology; Pathology; Iowa Neuroscience Institute; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984539532202771

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