Opponent control of behavior by dorsomedial striatal pathways depends on task demands and internal state

Scott S Bolkan; Iris R Stone; Lucas Pinto; Zoe C Ashwood; Jorge M Iravedra Garcia; Alison L Herman; Priyanka Singh; Akhil Bandi; Julia Cox; Christopher A Zimmerman; Jounhong Ryan Cho; Ben Engelhard; Jonathan W Pillow; Ilana B Witten

doi:10.1038/s41593-022-01021-9

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Opponent control of behavior by dorsomedial striatal pathways depends on task demands and internal state

Journal article

Peer reviewed

Opponent control of behavior by dorsomedial striatal pathways depends on task demands and internal state

Scott S Bolkan, Iris R Stone, Lucas Pinto, Zoe C Ashwood, Jorge M Iravedra Garcia, Alison L Herman, Priyanka Singh, Akhil Bandi, Julia Cox, Christopher A Zimmerman, …

Nature neuroscience, Vol.25(3), pp.345-357

03/01/2022

DOI: 10.1038/s41593-022-01021-9

PMCID: PMC8915388

PMID: 35260863

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https://www.ncbi.nlm.nih.gov/pmc/articles/8915388View

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Abstract

A classic view of the striatum holds that activity in direct and indirect pathways oppositely modulates motor output. Whether this involves direct control of movement, or reflects a cognitive process underlying movement, remains unresolved. Here we find that strong, opponent control of behavior by the two pathways of the dorsomedial striatum depends on the cognitive requirements of a task. Furthermore, a latent state model (a hidden Markov model with generalized linear model observations) reveals that-even within a single task-the contribution of the two pathways to behavior is state dependent. Specifically, the two pathways have large contributions in one of two states associated with a strategy of evidence accumulation, compared to a state associated with a strategy of repeating previous choices. Thus, both the demands imposed by a task, as well as the internal state of mice when performing a task, determine whether dorsomedial striatum pathways provide strong and opponent control of behavior.

Animals

Behavior, Animal

Choice Behavior

Corpus Striatum - metabolism

Mice

Movement

Neostriatum

Details

Title: Subtitle: Opponent control of behavior by dorsomedial striatal pathways depends on task demands and internal state
Creators: Scott S Bolkan - Princeton University
Iris R Stone - Princeton University
Lucas Pinto - Princeton University
Zoe C Ashwood - Princeton University
Jorge M Iravedra Garcia - Princeton University
Alison L Herman - Princeton University
Priyanka Singh - Princeton University
Akhil Bandi - Princeton University
Julia Cox - Princeton University
Christopher A Zimmerman - Princeton University
Jounhong Ryan Cho - Princeton University
Ben Engelhard - Princeton University
Jonathan W Pillow - Princeton University
Ilana B Witten - Princeton University
Resource Type: Journal article
Publication Details: Nature neuroscience, Vol.25(3), pp.345-357
DOI: 10.1038/s41593-022-01021-9
PMID: 35260863
PMCID: PMC8915388
NLM abbreviation: Nat Neurosci
ISSN: 1097-6256
eISSN: 1546-1726
Grant note: U01 NS090541 / NINDS NIH HHS K99 MH120047 / NIMH NIH HHS T32 MH065214 / NIMH NIH HHS F32 NS101871 / NINDS NIH HHS RF1 DA056404 / NIDA NIH HHS R01 DA047869 / NIDA NIH HHS R00 MH120047 / NIMH NIH HHS F32 MH118792 / NIMH NIH HHS R01 MH106689 / NIMH NIH HHS U19 NS104648 / NINDS NIH HHS
Language: English
Date published: 03/01/2022
Academic Unit: Psychological and Brain Sciences
Record Identifier: 9984944742102771

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