Journal article
Opportunity Nox: The Future of NADPH Oxidases as Therapeutic Targets in Cardiovascular Disease
Cardiovascular therapeutics, Vol.31(3), pp.125-137
2013
DOI: 10.1111/j.1755-5922.2011.00310.x
PMID: 22280098
Abstract
Over 40 years ago, NADPH (nicotinamide adenine dinucleotide phosphate) oxidase 2 (Nox2) was discovered in phagocytes and found to be essential in innate immunity. More than 20 years passed before additional Nox isoforms were discovered; and since then, studies have revealed that several of these isoforms (Nox1, Nox2, Nox4, and Nox5) are found in human cardiac and vascular cells and contribute to the pathogenesis of cardiovascular diseases (CVDs). Recently, major efforts have focused on identifying inhibitors capable of ameliorating Nox-mediated CVD. In this review, we briefly discuss the role of each Nox isoform in CVD, identify steps in Nox signaling that will serve as potential targets for the design of therapeutics, and highlight innovative strategies likely to yield effective Nox inhibitors within the next decade.
Details
- Title: Subtitle
- Opportunity Nox: The Future of NADPH Oxidases as Therapeutic Targets in Cardiovascular Disease
- Creators
- Jennifer STREETER - Department of Anatomy and Cell Biology, Free Radical and Radiation Biology, and Internal Medicine, University of Iowa, Iowa City, IA, United StatesWilliam THIEL - Department of Anatomy and Cell Biology, Free Radical and Radiation Biology, and Internal Medicine, University of Iowa, Iowa City, IA, United StatesKatharine BRIEGER - Department of Anatomy and Cell Biology, Free Radical and Radiation Biology, and Internal Medicine, University of Iowa, Iowa City, IA, United StatesFrancis J MILLER - Department of Anatomy and Cell Biology, Free Radical and Radiation Biology, and Internal Medicine, University of Iowa, Iowa City, IA, United States
- Resource Type
- Journal article
- Publication Details
- Cardiovascular therapeutics, Vol.31(3), pp.125-137
- Publisher
- Blackwell
- DOI
- 10.1111/j.1755-5922.2011.00310.x
- PMID
- 22280098
- ISSN
- 1755-5914
- eISSN
- 1755-5922
- Language
- English
- Date published
- 2013
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984094210802771
Metrics
19 Record Views