Optic disc edema in raised intracranial pressure. II. Early detection with fluorescein fundus angiography and stereoscopic color photography

S S Hayreh; M S Hayreh

doi:10.1001/archopht.1977.04450070143014

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Optic disc edema in raised intracranial pressure. II. Early detection with fluorescein fundus angiography and stereoscopic color photography

Journal article

Peer reviewed

Optic disc edema in raised intracranial pressure. II. Early detection with fluorescein fundus angiography and stereoscopic color photography

S S Hayreh and M S Hayreh

Archives of ophthalmology (1960), Vol.95(7), pp.1245-1254

07/1977

DOI: 10.1001/archopht.1977.04450070143014

PMID: 406883

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Abstract

Optic disc edema (ODE) due to chronic intracranial hypertension was produced experimentally in rhesus monkeys. Serial studies of fundus changes at frequent intervals, by routine ophthalmoscopy, steroscopic color photography, and fluorescein angiography, revealed that swelling of the optic disc was the first sign of ODE. Other early signs were striation of nerve fibers on the optic disc margins and peripapillary retina, blurring of the disc margins, hyperemia of the disc and capillary dilation, hemorrhages, and other retinal vascular changes; these usually appeared in that sequence. The classically described signs of early ODE were almost always absent. A normal fluorescein fundus angiogram during the incipient stage did not rule out ODE. Stereoscopic color fundus photography was the most sensitive means of detecting early ODE. Fluorescein angiography did not show changes till edema was of a mild to moderate degree; routine ophthalmoscopy was the least reliable method.

Reflex

Retinal Hemorrhage - etiology

Capillaries - pathology

Coloring Agents

Color

Choroid

Hyperemia - etiology

Macaca mulatta

Haplorhini

Intracranial Pressure

Animals

Optic Disk

Papilledema - complications

Papilledema - diagnosis

Nerve Fibers

Dilatation, Pathologic

Optic Nerve Diseases - etiology

Aneurysm - diagnosis

Fluorescein Angiography

Papilledema - etiology

Details

Title: Subtitle: Optic disc edema in raised intracranial pressure. II. Early detection with fluorescein fundus angiography and stereoscopic color photography
Creators: S S Hayreh
M S Hayreh
Resource Type: Journal article
Publication Details: Archives of ophthalmology (1960), Vol.95(7), pp.1245-1254
DOI: 10.1001/archopht.1977.04450070143014
PMID: 406883
NLM abbreviation: Arch Ophthalmol
ISSN: 0003-9950
eISSN: 1538-3601
Publisher: American Medical Association; United States
Language: English
Date published: 07/1977
Academic Unit: Ophthalmology and Visual Sciences
Record Identifier: 9983979917902771

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