Journal article
Optic disc haemorrhages at baseline as a risk factor for poor outcome in the Idiopathic Intracranial Hypertension Treatment Trial
British journal of ophthalmology, Vol.101(9), pp.1256-1260
09/2017
DOI: 10.1136/bjophthalmol-2016-309852
PMID: 28130349
Abstract
The risk of optic disc haemorrhages on visual outcome in idiopathic intracranial hypertension (IIH) is unknown. We report the type and frequency of optic disc haemorrhages and other funduscopic abnormalities at baseline in the study eye of the 133 subjects enrolled in the Idiopathic Intracranial Hypertension Treatment Trial completing 6 months of follow-up. We reviewed optic disc photographs to tabulate the frequency and type of optic disc haemorrhages, other funduscopic abnormalities and papilloedema grades of the study eye at baseline and analyse if their presence is associated with a poor visual outcome. 27.2% of subjects had nerve fibre layer haemorrhages in at least one eye. Five of seven, 71% of subjects that met criteria for treatment failure, had nerve fibre layer haemorrhages in at least one eye (Fisher's exact test: p=0.02). There was a good correlation between presence of nerve fibre layer haemorrhages and Frisén grade (Spearman's correlation, p=0.002; r=0.271). Subjects with nerve fibre layer haemorrhages had a higher cerebrospinal fluid pressure (40.0 mm water, p=0.04). There was poor correlation between nerve fibre layer haemorrhages at baseline and the perimetric mean deviation change at 6 months. Cotton wool spots were present in 4% of subjects, exudates in 3% and pseudodrusen in 4%. Nerve fibre layer haemorrhages are common in patients with IIH with mild visual loss and correlate with the severity of the papilloedema. They occur more frequently in treatment failure subjects and therefore may be associated with poor visual outcomes. NCT01003639, Post-results.
Details
- Title: Subtitle
- Optic disc haemorrhages at baseline as a risk factor for poor outcome in the Idiopathic Intracranial Hypertension Treatment Trial
- Creators
- Michael Wall - Departments of Neurology and Ophthalmology, University of Iowa College of Medicine, Iowa City, Iowa, USAMatthew J Thurtell - Department of Ophthalmology, University of Iowa College of Medicine, Iowa City, Iowa, USANORDIC Idiopathic Intracranial Hypertension Study Group
- Resource Type
- Journal article
- Publication Details
- British journal of ophthalmology, Vol.101(9), pp.1256-1260
- Publisher
- England
- DOI
- 10.1136/bjophthalmol-2016-309852
- PMID
- 28130349
- ISSN
- 0007-1161
- eISSN
- 1468-2079
- Grant note
- U10 EY017281 / NEI NIH HHS
- Language
- English
- Date published
- 09/2017
- Academic Unit
- Neurology; Ophthalmology and Visual Sciences
- Record Identifier
- 9983979972102771
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