Journal article
Optic disc morphology after arteritic anterior ischemic optic neuropathy
Ophthalmology (Rochester, Minn.), Vol.108(9), pp.1586-1594
2001
DOI: 10.1016/S0161-6420(01)00649-2
PMID: 11535455
Abstract
To evaluate the appearance of the nerve head in patients after giant cell arteritis–induced arteritic anterior ischemic optic neuropathy (A-AION).
Noncomparative clinical case series.
The study comprised 29 patients who presented with unilateral A-AION and temporal artery biopsy–proven giant cell arteritis. Stereoscopic optic disc photographs, taken of both the affected and unaffected eyes at the onset of the disease and after a follow-up period of 20.10 ± 25.36 months (median, 11 months; range, 2–102 months), were morphometrically evaluated.
Size and shape of the optic disc, neuroretinal rim, optic cup, and alpha and beta zones of parapapillary atrophy.
In the eyes after A-AION, at the end of the study, the neuroretinal rim was significantly (
P = 0.002) smaller, and the optic disc cup area was significantly (
P = 0.001) larger than those of the contralateral unaffected eyes. Alpha zone and beta zone of parapapillary atrophy did not vary significantly (
P > 0.50).
A-AION, like glaucomatous optic neuropathy, results in neuroretinal rim loss and optic disc cupping. However, in contrast to glaucoma, A-AION is not associated with an enlargement of parapapillary atrophy. The reasons and mechanisms responsible for these similarities and dissimilarities are discussed. Marked clinical, morphologic, and histopathologic similarities in optic disc cupping and loss of neuroretinal rim between A-AION and glaucomatous optic neuropathy are highly suggestive of a common mechanism for the development of the two diseases (i.e., ischemia of the optic nerve head). The subject is discussed at length.
Details
- Title: Subtitle
- Optic disc morphology after arteritic anterior ischemic optic neuropathy
- Creators
- Sohan Singh Hayreh - University of Iowa, Ophthalmology and Visual SciencesJost B Jonas - Department of Ophthalmology and Eye Hospital, Medical Faculty Mannheim of the Carola-Ruprechts-University Heidelberg, Mannheim, Germany
- Resource Type
- Journal article
- Publication Details
- Ophthalmology (Rochester, Minn.), Vol.108(9), pp.1586-1594
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S0161-6420(01)00649-2
- PMID
- 11535455
- ISSN
- 0161-6420
- eISSN
- 1549-4713
- Language
- English
- Date published
- 2001
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9984024893202771
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