Optic nerve head change in non-arteritic anterior ischemic optic neuropathy and its influence on visual outcome

Jost B Jonas; Sohan Singh Hayreh; Yong Tao; Konstantinos I Papastathopoulos; Florian Rensch

doi:10.1371/journal.pone.0037499

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Optic nerve head change in non-arteritic anterior ischemic optic neuropathy and its influence on visual outcome

Journal article

Open access

Peer reviewed

Optic nerve head change in non-arteritic anterior ischemic optic neuropathy and its influence on visual outcome

Jost B Jonas, Sohan Singh Hayreh, Yong Tao, Konstantinos I Papastathopoulos and Florian Rensch

PloS one, Vol.7(5), pp.e37499-e37499

2012

DOI: 10.1371/journal.pone.0037499

PMCID: PMC3357379

PMID: 22629408

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Abstract

To evaluate changes in cup/disc (C/D) diameter ratios and parapapillary atrophy in patients with non-arteritic anterior ischemic optic neuropathy (NA-AION), using morphometric methods. The clinical non-interventional study included 157 patients with unilateral or bilateral NA-AION. Optic disc photographs taken from both eyes at the end of follow-up were morphometrically examined. Follow-up was 86.3±70.3 months. Horizontal and vertical disc diameters (P = 0.30;P = 0.61, respectively), horizontal and vertical C/D ratios (P = 0.47;P = 0.19,resp.), and size of alpha zone and beta zone of parapapillary atrophy (P = 0.27;P = 0.32,resp.) did not differ significantly between affected eyes and contralateral normal eyes in patients with unilateral NA-AION. Similarly, horizontal and vertical disc diameters, horizontal and vertical C/D ratios, and size of alpha zone and beta zone did not vary significantly (all P>0.05) between the unaffected eyes of patients with unilateral NA-AION and the eyes of patients with bilateral NA-AION. Optic disc diameters, C/D ratios, size of alpha zone or beta zone of parapapillary atrophy were not significantly associated with final visual outcome in the eyes affected with NA-AION (all P>0.20) nor with the difference in final visual acuity between affected eyes and unaffected eyes in patients with unilateral NA-AION (all P>0.25). NA-AION did not affect C/D ratios nor alpha zone and beta zone of parapapillary atrophy. Optic disc size was not related to the final visual acuity outcome in NA-AION.

Optic Disk - physiopathology

Visual Fields - physiology

Follow-Up Studies

Humans

Middle Aged

Optic Neuropathy, Ischemic - physiopathology

Male

Atrophy

Optic Neuropathy, Ischemic - pathology

Adult

Female

Aged

Visual Acuity - physiology

Optic Disk - pathology

Details

Title: Subtitle: Optic nerve head change in non-arteritic anterior ischemic optic neuropathy and its influence on visual outcome
Creators: Jost B Jonas - Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Mannheim, Germany. Jost.Jonas@augen.ma.uni-heidelberg.de
Sohan Singh Hayreh
Yong Tao
Konstantinos I Papastathopoulos
Florian Rensch
Resource Type: Journal article
Publication Details: PloS one, Vol.7(5), pp.e37499-e37499
DOI: 10.1371/journal.pone.0037499
PMID: 22629408
PMCID: PMC3357379
NLM abbreviation: PLoS One
ISSN: 1932-6203
eISSN: 1932-6203
Publisher: United States
Grant note: EY-1576 / NEI NIH HHS
Language: English
Date published: 2012
Academic Unit: Ophthalmology and Visual Sciences
Record Identifier: 9983980060702771

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