Journal article
Optic neuropathy due to anaplastic large cell lymphoma
Seminars in ophthalmology, Vol.19(3-4), pp.81-87
01/01/2004
DOI: 10.1080/08820530490885848
PMID: 15590542
Abstract
Purpose. To report a case of anaplastic large cell lymphoma (ALCL) of the central nervous system (CNS) producing an optic neuropathy. Methods. Observational case report. Results. A 29-year-old male presented with new onset headaches. Magnetic resonance imaging (MRI) of the brain revealed a large enhancing parietal lobe mass. Ocular exam at that time was normal. Initial diagnoses included possible bacterial cerebritis and fungal abscess. Serial lumbar punctures showed increased white blood cells but cytology was negative. A brain biopsy was non-diagnostic. The patient then presented with a left optic neuropathy. Repeat MRI of the brain and orbits revealed infiltration of the clivus and left orbital apex including the optic nerve. The patient had elevated liver function studies and an abdominal ultrasound disclosed two hypoechoic lesions. Liver biopsy confirmed the diagnosis of ALK-1 positive ALCL. The patient was treated with chemotherapy but expired seven months after the initial presentation. Conclusion. ALCL should be considered to be a very rare but potential cause of optic neuropathy. To our knowledge, this is the first reported case of ALCL causing an optic neuropathy.
Details
- Title: Subtitle
- Optic neuropathy due to anaplastic large cell lymphoma
- Creators
- James HowardAndrew LeeMark GarwoodBrian LinkJames WooldridgePatricia Kirby
- Resource Type
- Journal article
- Publication Details
- Seminars in ophthalmology, Vol.19(3-4), pp.81-87
- Publisher
- Taylor & Francis
- DOI
- 10.1080/08820530490885848
- PMID
- 15590542
- ISSN
- 0882-0538
- eISSN
- 1744-5205
- Language
- English
- Date published
- 01/01/2004
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Pathology; Internal Medicine; Ophthalmology and Visual Sciences
- Record Identifier
- 9984094327302771
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