Optical Coherence Tomography Angiography of RPGR-Associated Retinitis Pigmentosa Suggests Foveal Avascular Zone is a Biomarker for Vision Loss

Peter H Tang; Ruben Jauregui; Stephen H Tsang; Alexander G Bassuk; Vinit B Mahajan

doi:10.3928/23258160-20190129-18

Back

Optical Coherence Tomography Angiography of RPGR-Associated Retinitis Pigmentosa Suggests Foveal Avascular Zone is a Biomarker for Vision Loss

Journal article

Peer reviewed

Optical Coherence Tomography Angiography of RPGR-Associated Retinitis Pigmentosa Suggests Foveal Avascular Zone is a Biomarker for Vision Loss

Peter H Tang, Ruben Jauregui, Stephen H Tsang, Alexander G Bassuk and Vinit B Mahajan

Ophthalmic surgery, lasers & imaging retina, Vol.50(2), pp.e44-e48

02/01/2019

DOI: 10.3928/23258160-20190129-18

PMCID: PMC7357791

PMID: 30768229

View Online

Abstract

RPGR-associated retinitis pigmentosa (RP) is a progressive disease with retina degeneration. Optical coherence tomography angiography (OCTA) is an imaging technique that provides novel insights. The authors report two affected male siblings who underwent OCTA imaging. The area of the foveal avascular zone (FAZ) was measured. Although the younger sibling exhibited more advanced clinical disease, his visual acuity was superior to his older sibling. OCTA imaging revealed a better preserved FAZ in the younger sibling as the reason for this. It also highlighted attenuation of choriocapillaris / choroid layers as biomarkers for disease severity. This provides new insights into retinal degeneration in RPGR-associated RP. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:e44-e48.].

Fluorescein Angiography - methods

Humans

Middle Aged

Retinitis Pigmentosa - genetics

Choroid

Male

Fovea Centralis - diagnostic imaging

Retinitis Pigmentosa - diagnostic imaging

Tomography, Optical Coherence - methods

Vision Disorders - diagnosis

Vision Disorders - genetics

Biomarkers

Eye Proteins - genetics

Capillaries

Details

Title: Subtitle: Optical Coherence Tomography Angiography of RPGR-Associated Retinitis Pigmentosa Suggests Foveal Avascular Zone is a Biomarker for Vision Loss
Creators: Peter H Tang
Ruben Jauregui
Stephen H Tsang
Alexander G Bassuk
Vinit B Mahajan
Resource Type: Journal article
Publication Details: Ophthalmic surgery, lasers & imaging retina, Vol.50(2), pp.e44-e48
DOI: 10.3928/23258160-20190129-18
PMID: 30768229
PMCID: PMC7357791
NLM abbreviation: Ophthalmic Surg Lasers Imaging Retina
ISSN: 2325-8160
eISSN: 2325-8179
Publisher: United States
Grant note: P30EY026877 / NIH HHS R01EY025225 / NIH HHS R21AG050437 / NIH HHS R01EY024698 / NIH HHS P30 EY019007 / NEI NIH HHS R01EY024665 / NIH HHS
Language: English
Date published: 02/01/2019
Academic Unit: Neurology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics)
Record Identifier: 9984070833002771

Metrics

30 Record Views

5 Times Cited - Web of Science

See more details