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Optical coherence tomography grading reproducibility during the Comparison of Age-related Macular Degeneration Treatments Trials
Journal article   Open access   Peer reviewed

Optical coherence tomography grading reproducibility during the Comparison of Age-related Macular Degeneration Treatments Trials

Francis Char DeCroos, Cynthia A Toth, Sandra S Stinnett, Cynthia S Heydary, Russell Burns, Glenn J Jaffe and CATT Research Group
Ophthalmology (Rochester, Minn.), Vol.119(12), pp.2549-2557
12/2012
DOI: 10.1016/j.ophtha.2012.06.040
PMCID: PMC3631582
PMID: 22939114
url
https://www.ncbi.nlm.nih.gov/pmc/articles/3631582View
Open Access

Abstract

To report reading center reproducibility during grading of Stratus optical coherence tomography (OCT) (Carl Zeiss Meditec, Dublin, CA) images obtained during the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT). Prospective, clinical trial. Independent reading teams reevaluated 270 OCT scans randomly sampled from the first 2 years of CATT enrollment. To assess temporal drift, a cohort of 23 scans submitted during the initial portion of the CATT study was longitudinally followed with serial reproducibility analysis. The CATT readers performed standardized grading of OCT images. A reader team, composed of 2 independent readers and a senior reader, evaluated each scan. Grading included the CATT OCT end points of total thickness at the foveal center point and intraretinal fluid (IRF), subretinal fluid (SRF), and subretinal pigment epithelium (RPE) fluid. Independent reading teams masked to the results of initial grading reevaluated scans to determine the reproducibility of qualitative grading and measurements. Categorical grading agreement was reported using percent agreement and kappa statistic, and measurement agreement was reported using intraclass correlations and paired differences. Reading center teams reproducibly graded IRF (percent agreement = 73%, kappa = 0.48; 95% confidence interval [CI], 0.38-0.58), SRF (percent agreement = 90%; kappa = 0.80; 95% CI, 0.73-0.87), and sub-RPE fluid (percent agreement 88%; kappa = 0.75; 95% CI, 0.67-0.83). For independent reading center team measurements of total thickness at the foveal center point, the intraclass correlation was 0.99 (95% CI, 0.99-0.99), and the mean paired difference between reading center teams was 4 μm (95% limits of agreement, -55 to 47 μm). There was no qualitative or quantitative grading drift. The standardized protocols used to evaluate OCT scans from the CATT study were reproducible. The methods used are suitable to monitor OCT imaging data from a large, neovascular age-related macular degeneration, interventional, multicenter study. The author(s) have no proprietary or commercial interest in any materials discussed in this article.
 Reproducibility of Results Antibodies, Monoclonal, Humanized - therapeutic use Prospective Studies Double-Blind Method Macular Degeneration - classification Humans Epiretinal Membrane - diagnosis Vascular Endothelial Growth Factor A - antagonists & inhibitors Macular Degeneration - diagnosis Macular Degeneration - drug therapy Bevacizumab Ranibizumab Subretinal Fluid Angiogenesis Inhibitors - therapeutic use Tomography, Optical Coherence - standards Retina - pathology Visual Acuity - physiology Observer Variation Quality Control

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